CBL1337 | Anti-PECAM-1 Antibody, clone 390

CBL1337
500 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IHC, IP, FUNCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL1337
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-PECAM-1 Antibody, clone 390
      Alternate Names
      • CD31
      Background InformationCD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1) is a type I integral membrane glycoprotein, and a member of the immunoglobulin superfamily of cell surface receptors. PECAM-1 is constitutively expressed on the surface of endothelial cells where it is concentrated at cell junctions. PECAM-1 is also expressed at low levels on all leukocytes and platelets. Homotypic interaction of CD31 is important in cell-cell interaction, cell-matrix interaction and signal transduction.
      References
      Product Information
      FormatPurified
      Control
      • Jurkat and Raji cells, tonsil tissue
      PresentationProtein A Purified mouse immunoglobulin in 100mM borate buffered saline, pH 8.0, containing no preservative.
      Applications
      ApplicationAnti-PECAM-1 Antibody, clone 390 is an antibody against PECAM-1 for use in FC, IH & IP.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunoprecipitation
      • Affects Function
      Application NotesFlow Cytometry: 1 μg/10e6 cells.

      Immunohistochemistry: acteone fixed frozen tissue sections

      Immunoprecipitation

      Blocking of cell adhesion: CBL1337 inhibits aggregation of L cells transfected with a variant form of CD31 (DeLisser, 1993)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMouse leukocyte cell line 32D
      Clone390
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityCBL1337 recognizes mouse PECAM-1, a 130-140 kDa type 1 integral membrane glycoprotein. This antibody has been shown to inhibit the aggregation of L cells transfected with a variant form of PECAM-1 (DeLisser, 1993).
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PECAM1
      • EndoCAM
      • GPIIA
      • PECAM-1
      • CD31
      • CD31/EndoCAM
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16284 # This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
      SIZE: 738 amino acids; 82536 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart.
      PTM: Phosphorylated on Ser and Tyr residues after cellular activation.
      SIMILARITY: SwissProt: P16284 ## Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RAT ANTI-MOUSE PECAM-1 [CD31] MONOCLONAL ANTIBODY - 2020263 2020263
      RAT ANTI-MOUSE PECAM-1 [CD31] -2510166 2510166
      RAT ANTI-MOUSE PECAM-1 [CD31] -2549003 2549003
      RAT ANTI-MOUSE PECAM-1 [CD31] -2581331 2581331
      RAT ANTI-MOUSE PECAM-1 [CD31] -2718316 2718316
      RAT ANTI-MOUSE PECAM-1 [CD31] -2746564 2746564
      RAT ANTI-MOUSE PECAM-1 [CD31] -2764017 2764017
      RAT ANTI-MOUSE PECAM-1 [CD31] -2795077 2795077
      RAT ANTI-MOUSE PECAM-1 [CD31] MONOCLONAL ANTIBODY - 2061423 2061423
      RAT ANTI-MOUSE PECAM-1 [CD31] MONOCLONAL ANTIBODY - 2186315 2186315

      References

      Reference overviewApplicationPub Med ID
      Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity.
      Hu, Y; Ru, N; Xiao, H; Chaturbedi, A; Hoa, NT; Tian, XJ; Zhang, H; Ke, C; Yan, F; Nelson, J; Li, Z; Gramer, R; Yu, L; Siegel, E; Zhang, X; Jia, Z; Jadus, MR; Limoli, CL; Linskey, ME; Xing, J; Zhou, YH
      PloS one  8  e80898  2013

      Show Abstract
      Immunofluorescence24282558 24282558
      Elutriated stem cells derived from the adult bone marrow differentiate into insulin-producing cells in vivo and reverse chemical diabetes.
      Svetlana Iskovich,Nitza Goldenberg-Cohen,Jerry Stein,Isaac Yaniv,Ina Fabian,Nadir Askenasy
      Stem cells and development  21  2012

      Show Abstract
      21457125 21457125
      Targeting Vascular Amyloid in Arterioles of Alzheimer Disease Transgenic Mice With Amyloid β Protein Antibody-Coated Nanoparticles.
      Poduslo JF, Hultman KL, Curran GL, Preboske GM, Chamberlain R, Marjańska M, Garwood M, Jack CR Jr, Wengenack TM.
      Journal of neuropathology and experimental neurology  70  653-61  2011

      Show Abstract
      21760540 21760540
      Nestin-driven green fluorescent protein as an imaging marker for nascent blood vessels in mouse models of cancer.
      Hoffman RM
      Methods in molecular biology (Clifton, N.J.)  689  183-204  2011

      Show Abstract
      21153793 21153793
      Dual-color imaging of tumor angiogenesis.
      Robert M Hoffman, Robert M Hoffman, Robert M Hoffman
      Methods in molecular biology (Clifton, N.J.)  515  1-17  2009

      Show Abstract
      19378118 19378118
      A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis.
      K Hayashi, K Yamauchi, N Yamamoto, H Tsuchiya, K Tomita, M Bouvet, J Wessels, R M Hoffman, K Hayashi, K Yamauchi, N Yamamoto, H Tsuchiya, K Tomita, M Bouvet, J Wessels, R M Hoffman
      Cell proliferation  42  75-82  2009

      Show Abstract
      19143765 19143765
      A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions.
      Niclou, SP; Danzeisen, C; Eikesdal, HP; Wiig, H; Brons, NH; Poli, AM; Svendsen, A; Torsvik, A; Enger, PØ; Terzis, JA; Bjerkvig, R
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  22  3120-8  2008

      Show Abstract Full Text Article
      18495755 18495755
      Chemotherapy targets the hair-follicle vascular network but not the stem cells.
      Amoh, Y; Li, L; Katsuoka, K; Hoffman, RM
      The Journal of investigative dermatology  127  11-5  2007

      Show Abstract
      16841031 16841031
      The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer.
      Yong Ji, Katsuhiro Hayashi, Yasuyuki Amoh, Kazuhiko Tsuji, Kensuke Yamauchi, Norio Yamamoto, Hiroyuki Tsuchiya, Katsuro Tomita, Michael Bouvet, Robert M Hoffman
      Anticancer research  27  713-8  2007

      Show Abstract
      17465193 17465193
      Color-coded fluorescence imaging of tumor-host interactions.
      Robert M Hoffman, Meng Yang
      Nature protocols  1  928-35  2006

      Show Abstract
      17406326 17406326

      Brochure

      Title
      Human Stem Cell Systems

      Data Sheet

      Title
      Anti-PECAM-1, clone 390 - Data Sheet

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      Alternative Format

      Catalogue Number Description  
      CBL1337F Anti-PECAM-1 Antibody, clone 390, FITC conjugated Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies