06-937 | Anti-phospho-STAT6 (Tyr641) Antibody

06-937
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-937
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-STAT6 (Tyr641) Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
      Applications
      ApplicationThis Anti-phospho-STAT6 (Tyr641) Antibody is validated for use in WB for the detection of phospho-STAT6 (Tyr641).
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 631-645 of human STAT6 (C-PEQMGKDGRGpYVPAT)
      HostRabbit
      Specificityphospho-STAT6
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
      Gene Symbol
      • STAT6
      • D12S1644
      • IL-4-STAT
      • STAT6C
      • STAT6B
      Modifications
      • Phosphorylation
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
      SIZE: 847 amino acids; 94135 Da
      SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
      PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
      SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
      Molecular Weight100kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on lysates of HepG2 cells, serum starved, then stimulated with IL-4
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-STAT6 (Tyr641) (rabbit polyclonal IgG) - 2370087 2370087
      Anti-phospho-STAT6 (Tyr641) - 2420382 2420382
      Anti-phospho-STAT6 (Tyr641) - 18447 18447
      Anti-phospho-STAT6 (Tyr641) - 23931 23931
      Anti-phospho-STAT6 (Tyr641) - 2510139 2510139
      Anti-phospho-STAT6 (Tyr641) - 26536 26536
      Anti-phospho-STAT6 (Tyr641) - DAM1655260 DAM1655260
      Anti-phospho-STAT6 (Tyr641) -2728371 2728371

      References

      Reference overviewPub Med ID
      Classical and Alternative Activation and Metalloproteinase Expression Occurs in Foam Cell Macrophages in Male and Female ApoE Null Mice in the Absence of T and B Lymphocytes.
      Hayes, EM; Tsaousi, A; Di Gregoli, K; Jenkinson, SR; Bond, AR; Johnson, JL; Bevan, L; Thomas, AC; Newby, AC
      Frontiers in immunology  5  537  2014

      Show Abstract
      25389425 25389425
      Defective GATA-3 expression in Th2 LCR-deficient mice.
      Soo Seok Hwang,Kiwan Kim,Gap Ryol Lee
      Biochemical and biophysical research communications  410  2011

      Show Abstract
      21703230 21703230
      Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis.
      Quelle, F W, et al.
      Mol. Cell. Biol., 15: 3336-43 (1995)  1995

      Show Abstract
      7760829 7760829
      An interleukin-4-induced transcription factor: IL-4 Stat.
      Hou, J, et al.
      Science, 265: 1701-6 (1994)  1994

      Show Abstract
      8085155 8085155

      Technical Info

      Title
      JAK/STAT Signaling Research Focus

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies