05-590 | Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

05-590
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-590
      ReplacesMAB3702
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-STAT6 (Tyr641) Antibody, clone 16E12
      References
      Product Information
      FormatPurified
      Presentation100µg of lyophilized thiophilic and size exclusion chromatography purified mouse IgG1 from 1mL 2x PBS / 0.09 % Na-azide / PEG and Sucrose. Reconstitute with 100 µL H2O (15 min, RT) for a final concentration of 1 mg/mL. Store at -20°C.
      Applications
      ApplicationDetect phospho-STAT6 (Tyr641) also known as signal transducer & activator of transcription 6 with Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 (mouse monoclonal antibody), that has been demonstrated to work in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to residues of human STAT6 (Tyr641); recognizes STAT6 phosphorylated on Tyrosine 641.
      Cloneclone 16E12
      HostMouse
      Specificityphosphorylated STAT6
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
      Gene Symbol
      • STAT6
      • STAT6C
      • D12S1644
      • STAT6B
      • IL-4-STAT
      Modifications
      • Phosphorylation
      Purification MethodThiophilic adsoption and size exclusion chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
      SIZE: 847 amino acids; 94135 Da
      SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
      PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
      SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
      Molecular Weight100kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from IL4-stimulated HepG2 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-STAT6 (Tyr641) - 20253 20253
      Anti-phospho-STAT6 (Tyr641) - 25346 25346
      Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2433264 2433264
      Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 1951497 1951497
      Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2110471 2110471
      Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2210329 2210329
      Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2274021 2274021
      Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2326975 2326975
      Anti-phospho-STAT6 (Y641), clone 16E12 - 2031317 2031317
      Anti-phospho-STAT6 (Y641), clone 16E12 - 2033626 2033626

      Brochure

      Title
      Pathways and Biomarkers of JAK/STAT Signaling

      Technical Info

      Title
      JAK/STAT Signaling Research Focus

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies