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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
31 Mai 2012
wird geladen
A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control.
| Produktinformationen | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | Hh signaling in Shh-light2 assay | ||
| Primary Target IC50 | 20 nM | ||
| Secondary target | in P2Ptch-/-cells (IC50 = 50 nM) | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Cell permeable | Ja | ||
| Purity | ≥97% by HPLC | ||
| Chemische Formel | C27H41NO2 | ||
| RTECS | GY0750000 | ||
| CAS-Nummer | 4449-51-8 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |
||
