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Merck

15759

Poloxamer 188

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12352104
NACRES:
NA.25
MDL number:
MFCD00082049

Key Documents

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form

solid

Quality Level

200

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤1 ppm ethylene oxide, ≤1.0% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH3OH

pH

5.0-7.5 (100 g/L in H2O), 6.0-7.5 (25 g/L in H2O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Related Categories

Application


  • Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

Legal Information

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6034
BCCN6032
BCCN0958
BCCL8783
BCCM5491

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Wei Xu et al.
Drug delivery, 19(4), 208-219 (2012-05-31)
The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.
Liyan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
Céline Durand-Gasselin et al.
Langmuir : the ACS journal of surfaces and colloids, 27(20), 12329-12335 (2011-09-29)
Aggregation of thermosensitive polymer-coated gold nanoparticles was performed in aqueous solution in the presence of a triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic P123, PEO(20)-PPO(68)-PEO(20)). The gold nanoparticles, AuNPs, which are covered by thermosensitive statistical copolymers poly(EO(x)-st-PO(y)), aggregate when the
Wanhua Feng et al.
Colloids and surfaces. B, Biointerfaces, 105, 43-50 (2013-01-29)
The interaction between bacteria and surfaces is central to many environmental, industrial and medical applications. Surfactants are commonly used in these applications and can potentially influence the bacterium/surface interaction. The effect of surfactants upon bacterial cell surface thermodynamic properties was
Houjian Gong et al.
Langmuir : the ACS journal of surfaces and colloids, 28(38), 13590-13600 (2012-09-08)
The block polyethers PEO-PPO-ph-PPO-PEO (BPE) and PPO-PEO-ph-PEO-PPO (BEP) are synthesized by anionic polymerization using bisphenol A as initiator. Compared with Pluronic P123, the aggregation behaviors of BPE and BEP at an air/water interface are investigated by the surface tension and
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