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Publications Using the CellASIC® ONIX Microfluidic System

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The CellASIC® ONIX2 Microfluidic System is the next generation of a well-established and highly published technology. The ability to couple your powerful microscope optics with reliable, extremely controllable cell culture is no longer novel, but now is seen as necessary for conducting precision manipulations in live cell analysis. See how scientists are using this easy-to-use system to make and publish discoveries never before possible.


Yeast continues to be an exceptional eukaryotic model for many key conserved molecular mechanisms including genomic regulation, cell cycle, and energy metabolism and signaling. Track yeast over multiple generations while maintaining a single focal plane using specialized yeast microfluidic plates on the ONIX2 system.


Bacteria and Fungi

From individual cell growth and division, to colony formation and response to change, bacterial research continues to be critical in medical and environmental applications. The ONIX2’s innovative bacterial microfluidic chambers hold cells in a single focal plane, allowing you to induce and follow cell events during high magnification viewing.



Mammalian cell studies involving genetic and metabolic shifts in response to environmental changes such as developmental signals, gradients, or hypoxia benefit greatly from precisely controlled culture. The ONIX2 microfluidic system has customized mammalian cell culture plates for use in creating standing spatial gradients, controlling influx and efflux of media to promote a more in vivo-like environment during imaging.
  1. Zambrano S, De Toma I, Piffer A, Bianchi ME, Agresti A; NF-κB oscillations translate into functionally related patterns of gene expression; eLife 2016; 10.7554/eLife .09100;
  2. Changou CA, Chen Y-R, Xing L, Yen Y, Chuang FYS, Cheng RH, Bold RJ, Ann DK, Kung H-J; Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy. PNAS, Sep 2014; 111: 14147 - 14152.
  3. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA; Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. PNAS, Apr 2014; 111: 5896 - 5901.