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Merck

BP464

Prednisolone

British Pharmacopoeia (BP) Assay Standard

Synonyme(s) :

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

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A propos de cet article

Formule empirique (notation de Hill) :
C21H28O5
Numéro CAS:
50-24-8
Poids moléculaire :
360.44
EC Number:
200-021-7
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
1354103
MDL number:
MFCD00003649

Principaux documents

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InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

OIGNJSKKLXVSLS-VWUMJDOOSA-N

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

grade

pharmaceutical primary standard

API family

prednisolone

form

crystalline

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

240 °C (dec.) (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

Gene Information

human ... NR3C1(2908)

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Catégories apparentées

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Prednisolone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Estriol Cream
  • Prednisolone Sodium Phosphate Ear Drops
  • Prednisolone Sodium Phosphate Eye Drops
  • Prednisolone Tablets
  • Prednisolone Soluble Tablets
  • Prednisolone Enema
  • Prednisolone Sodium Phosphate Oral Solution
  • Prednisolone Gastro-resistant Tablets

    • Other Notes

    Sales restrictions may apply.

    pictograms

    Health hazard
    GHS08

    signalword

    Danger

    hcodes

    H360FD

    Hazard Classifications

    Repr. 1B

    Classe de stockage

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 2

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    Certificats d'analyse (COA)

    Lot/Batch Number

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    Consulter la Bibliothèque de documents

    Ramachandran Venkitaraman et al.
    European urology, 67(4), 673-679 (2014-12-03)
    Prednisolone is widely used as secondary hormonal treatment for castration-resistant prostate cancer (CRPC). We hypothesised that dexamethasone, another corticosteroid, is more active. To compare the activity of prednisolone and dexamethasone in CRPC. This single-centre, randomised, phase 2 trial was performed
    Eng Cern Gan et al.
    International forum of allergy & rhinology, 4(11), 877-884 (2014-08-20)
    The endoscopically magnified operative field in functional endoscopic sinus surgery (FESS) makes even a small amount of bleeding a potentially significant hindrance. It is thought that irrigation with hot saline during surgery may improve surgical field of view by producing
    T Bakchoul et al.
    Journal of thrombosis and haemostasis : JTH, 12(6), 871-878 (2014-03-25)
    Heparin, the standard perioperative anticoagulant for the prevention of graft vessel thrombosis in patients undergoing liver transplantation (LT), binds to the chemokine platelet factor 4 (PF4). Antibodies that are formed against the resulting PF4/heparin complexes can induce heparin-induced thrombocytopenia. LT
    C Motteram et al.
    Reproductive biomedicine online, 30(4), 340-348 (2015-02-14)
    The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfers (FET) in IVF and intracytoplasmic sperm injection cycles. Cases (n = 485) and
    Murat Baş et al.
    The New England journal of medicine, 372(5), 418-425 (2015-01-30)
    Angioedema induced by treatment with angiotensin-converting-enzyme (ACE) inhibitors accounts for one third of angioedema cases in the emergency room; it is usually manifested in the upper airway and the head and neck region. There is no approved treatment for this
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