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Merck

BP578

Dexaméthasone

British Pharmacopoeia (BP) Assay Standard

Synonyme(s) :

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-méthylpregna-1,4-diène-3,20-dione, 9α-Fluoro-16α-méthyl-11β,17α,21-trihydroxy-1,4-pregnadiène-3,20-dione, 9α-Fluoro-16α-méthylprednisolone, Prednisolone F

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A propos de cet article

Formule empirique (notation de Hill) :
C22H29FO5
Numéro CAS:
50-02-2
Poids moléculaire :
392.46
EC Number:
200-003-9
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
2066651
MDL number:
MFCD00064136

Principaux documents

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InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

grade

pharmaceutical primary standard

API family

dexamethasone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

262-264 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

Gene Information

human ... NR3C1(2908)

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Catégories apparentées

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Tobramycin and Dexamethasone Eye Drops, Suspension
  • Dexamethasone Sodium Phosphate Oral Solution
  • Hydrocortisone Sodium Succinate Injection
  • Prednisolone Tablets
  • Dexamethasone Eye Drops, Suspension
  • Dexamethasone Sodium Phosphate Eye Drops, Solution
  • Dexamethasone and Neomycin Ear Spray
  • Betamethasone Tablets
  • Dexamethasone Tablets

    • Biochem/physiol Actions

    Agent anti-inflammatoire du type glucocorticoïde
    Agent anti-inflammatoire du type glucocorticoïde. Régule la survie, la croissance et la différenciation des lymphocytes T. Inhibe l′induction de l′oxyde nitrique synthase.

    Other Notes

    Sales restrictions may apply.

    pictograms

    Health hazard
    GHS08

    signalword

    Danger

    hcodes

    H360FD

    Hazard Classifications

    Repr. 1B

    Classe de stockage

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    Certificats d'analyse (COA)

    Lot/Batch Number

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    Consulter la Bibliothèque de documents

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    Michael J White et al.
    Cell, 159(7), 1549-1562 (2014-12-20)
    Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the suggestion that caspases are activated not just to kill
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    Altered functioning of the hypothalamic-pituitary-adrenal axis (HPA-axis) has been associated with depression, but findings have been inconsistent. Among older depressed persons, both hyperactivity and hypo-activity of the HPA-axis were demonstrated. However, most studies were population-based studies, with single cortisol measurements
    Yijin Wang et al.
    Gastroenterology, 146(7), 1775-1783 (2014-03-04)
    Many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis E virus (HEV). Although chronic HEV infection is generally associated with immunosuppressive therapies, little is known about how different immunosuppressants affect HEV infection. A subgenomic HEV
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