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Merck

C2400000

Clonidine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C9H9Cl2N3 · HCl
Numéro CAS:
4205-91-8
Poids moléculaire :
266.55
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329775001
MDL number:
MFCD00036705
Beilstein/REAXYS Number:
4163525

Principaux documents

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InChI

1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

SMILES string

Cl[H].Clc1cccc(Cl)c1NC2=NCCN2

InChI key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

clonidine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Catégories apparentées

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clonidine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

hcodes

H301,H330

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Yanyan Qiu et al.
Scientific reports, 4, 6605-6605 (2014-10-14)
This study examined whether a novel imidazoline I₂ receptor ligand CR4056 could serve as a discriminative stimulus and whether it shares similar discriminative stimulus effects with other reported I₂ receptor ligands. Eight male Sprague-Dawley rats were trained to discriminate 10.0 mg/kg
Paula E Park et al.
Addiction biology, 20(2), 275-284 (2013-12-18)
Opioids represent effective drugs for the relief of pain, yet chronic opioid use often leads to a state of increased sensitivity to pain that is exacerbated during withdrawal. A sensitization of pain-related negative affect has been hypothesized to closely interact
Kalpashri Kesavan et al.
Respiratory physiology & neurobiology, 201, 93-100 (2014-07-11)
Sedative-analgesics are often given to newborn infants and are known to affect many components of the autonomic nervous system. While morphine is most frequently used, α-2 adrenergic receptor agonists are being increasingly used in this population. Alpha-2 adrenergic receptors agonists
Craige C Wrenn et al.
Neuroscience letters, 585, 109-113 (2014-11-30)
Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists.
Sonia Goineau et al.
Fundamental & clinical pharmacology, 29(1), 86-94 (2014-06-13)
Several methods are used to evaluate gastric emptying (GE) in rats, which is an important endpoint in preclinical drug development. Although phenol red model or monitoring of plasma acetaminophen levels are well-established procedures for GE assessment, their capacity to detect
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