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F7878

Folinic acid calcium salt hydrate

analytical standard

Synonyme(s) :

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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A propos de cet article

Formule empirique (notation de Hill) :
C20H21CaN7O7 · xH2O
Numéro CAS:
1492-18-8
Poids moléculaire :
511.50 (anhydrous basis)
MDL number:
MFCD00149463
UNSPSC Code:
41116107
PubChem Substance ID:
24894951
NACRES:
NA.24
Beilstein/REAXYS Number:
5723924
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biological source

synthetic (organic)

Quality Level

100

grade

analytical standard

assay

≥90.0%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

yellow to orange

mp

240-250 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

General description

Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues.

Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry.

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11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
WXBF4236V
WXBF0751V
WXBF1931V
WXBD7643V
WXBD9506V

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Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum
Schofield.CR, et al.
Journal of Chromatography. B, Biomedical Applications, 1002, 169-175 (2015)
Preparation, characterization and physicochemical properties of DOPE-PEG2000 stabilized oleic acid-soy lecithin liposomes (POLL)
Suk ERV and Misran M
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 513, 267-273 (2017)
The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia
Kurtys E, et al.
Neurochemistry International, 99, 206-214 (2016)
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