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Merck

PHR1017

Phenylephrine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

(R)-(−)-Phenylephrine hydrochloride, PHE, (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride

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A propos de cet article

Formule linéaire :
HOC6H4CH(CH2NHCH3)OH·HCl
Numéro CAS:
61-76-7
Poids moléculaire :
203.67
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823048
EC Number:
200-517-3
Beilstein/REAXYS Number:
4158948
MDL number:
MFCD00012605

Principaux documents

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Nom du produit

Phenylephrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

SMILES string

OC1=CC([C@H](CNC)O)=CC=C1.Cl

grade

certified reference material
pharmaceutical secondary standard

agency

USP 1533002
traceable to Ph. Eur. P1250000

API family

phenylephrine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

143-145 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Phenylephrine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Phenylephrine Hydrochloride is classified under the category of sympathomimetic drugs. It is generally utilized as a nasal decongestant.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7786 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1B

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

  5. Is (R)-(-)-Phenylephrine hydrochloride the same as L-Phenylephrine hydrochloride?

    (R)-(-)-Phenylephrine hydrochloride is also named l-Phenylephrine hydrochloride (lower case el) or Levophenylephrine hydrochloride.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Determination of phenylephrine hydrochloride and chlorpheniramine maleate in binary mixture using chemometric-assisted spectrophotometric and high-performance liquid chromatographic-UV methods
Al-Shaalan NH
Journal of Saudi Chemical Society, 14(1), 15-21 (2010)
Simultaneous high performance liquid chromatographic and derivative ratio spectra spectrophotometry determination of chlorpheniramine maleate and phenylephrine hydrochloride
Erk N and Kartal M
Il Farmaco (Societa Chimica Italiana : 1989), 53(8-9), 617-622 (1998)
Degradation of phenylephrine hydrochloride in tablet formulations containing aspirin
Troup AE and Mitchner H
Journal of Pharmaceutical Sciences, 53(4), 375-379 (1964)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)
Patrícia Passaglia et al.
Brain, behavior, and immunity, 88, 606-618 (2020-04-27)
Angiotensin-(1-7) [Ang-(1-7)] is an angiotensin-derived neuropeptide with potential anti-hypertensive and anti-inflammatory properties. However, a possible action of Ang-(1-7) in neuroimmune interactions to regulate inflammatory response has not been explored. Thus, the aim of this study was to determine whether the
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