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Merck

PHR1097

L-Tyrosine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

3-(4-Hydroxyphényl)-L-alanine, Acide (S)-2-amino-3-(4-hydroxyphlényl)propionique

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A propos de cet article

Formule linéaire :
4-(HO)C6H4CH2CH(NH2)CO2H
Numéro CAS:
60-18-4
Poids moléculaire :
181.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823119
EC Number:
200-460-4
Beilstein/REAXYS Number:
392441
MDL number:
MFCD00002606

Principaux documents

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Nom du produit

L-Tyrosine, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

OUYCCCASQSFEME-QMMMGPOBSA-N

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

SMILES string

N[C@@H](Cc1ccc(O)cc1)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. T2900000
traceable to USP 1705006

API family

tyrosine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

Other Notes

Acide aminé précurseur de la dopamine et d′autres catécholamines
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7163 in the slot below. This is an example certificate only and may not be the lot that you receive.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

L-Tyrosine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by a liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 1

Certificats d'analyse (COA)

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High-performance liquid chromatographic analysis of biogenic amines in pharmaceutical products containing Citrus aurantium
Viana C, et al.
Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 30(4), 634-642 (2013)
Vincent Dunet et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(2), 207-214 (2012-02-04)
For the past decade, PET with (18)F-fluoro-ethyl-tyrosine ((18)F-FET) has been used in the evaluation of patients with primary brain tumors (PBTs), but so far series have reported only a limited number of patients. The purpose of this systematic review and
Verena Rahm et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(4), 546-550 (2014-02-26)
Low-grade gliomas (LGGs) may harbor malignant foci, which are characterized by increased tumor cellularity and angiogenesis. We used diffusion-weighted MR imaging (apparent diffusion coefficient [ADC]) and PET with the amino acid O-(2-(18)F-fluorethyl)-L-tyrosine ((18)F-FET) to search for focal changes of diffusion
T Eklundh et al.
Journal of psychiatric research, 30(3), 201-208 (1996-05-01)
In order to elucidate methodological aspects of CSF investigations, 14 healthy male subjects were lumbar-punctured at the L4-5 level following a standardised procedure. CSF concentrations of precursors, transmitters and transmitter metabolites were used as dependent variables, while age, height, body
Alena Volgusheva et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7223-7228 (2013-04-17)
Photobiological H2 production is an attractive option for renewable solar fuels. Sulfur-deprived cells of Chlamydomonas reinhardtii have been shown to produce hydrogen with the highest efficiency among photobiological systems. We have investigated the photosynthetic reactions during sulfur deprivation and H2
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