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Merck

PHR1141

Ondansetron Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Ondansetron hydrochloride dihydrate, 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F

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A propos de cet article

Formule empirique (notation de Hill) :
C18H19N3O · HCl · 2H2O
Numéro CAS:
103639-04-9
Poids moléculaire :
365.85
NACRES:
NA.24
PubChem Substance ID:
329823161
UNSPSC Code:
41116107
MDL number:
MFCD00374371

Principaux documents

Voir toute la documentation
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000218, traceable to USP 1478582

API family

ondansetron

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C

InChI

1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

InChI key

VRSLTNZJOUZKLX-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359)

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Catégories apparentées

General description

Ondansetron Hydrochloride acts as a 5HT3 (serotonin) antagonist and is a powerful antiemetic drug. It is widely used for the prevention and treatment of nausea and vomiting related to post-operative states, cancer chemotherapy and radiotherapy, and chronic medical illness. It has been found to exhibit inconsistent bioavailability resulting from its poor aqueous solubility and high first-pass hepatic metabolism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ondansetron Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by spectrophotometric, electrochemical, and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

5-HT3 serotonin receptor antagonist

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7141 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

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Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Fast dissolving sublingual films of ondansetron hydrochloride: effect of additives on in vitro drug release and mucosal permeation
Koland M, et al.
Journal of Young Pharmacists : Jyp, 2(3), 216-222 (2010)
Determination of ondansetron hydrochloride by a liquid membrane potentiometric sensor based on room temperature ionic liquids
Faridbod F, et al.
International Journal of Electrochemical Science, 8(8), 10461-10472 (2013)
Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential
Beg S, et al.
Colloids and Surfaces. B, Biointerfaces, 101(3), 414-423 (2013)
Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets
Khan S, et al.
Aaps Pharmscitech, 8(2), E127-E133 (2007)
UV spectrophotometric method for determination of ondansetron hydrochloride in pure and its formulation
Kalaichelvi R,et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 151-152 (2012)
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