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Merck

PHR1168

Ofloxacin

Pharmaceutical Secondary Standard; Certified Reference Material

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A propos de cet article

Formule empirique (notation de Hill) :
C18H20FN3O4
Numéro CAS:
82419-36-1
Poids moléculaire :
361.37
UNSPSC Code:
41116107
PubChem Substance ID:
329823185
NACRES:
NA.24
MDL number:
MFCD00226105

Principaux documents

Voir toute la documentation
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SMILES string

Fc1cc2c3[n](cc([c]2=O)C(=O)O)C(COc3c1N4CCN(CC4)C)C

InChI

1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)

InChI key

GSDSWSVVBLHKDQ-UHFFFAOYSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1478108

API family

ofloxacin, ofloxacin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ofloxacin is an orally administered antimicrobial drug that is classified under the group of fluoroquinolones. It has high potency and shows a broad-spectrum antibacterial performance, as well as short selection of resistant bacteria.

Application

Ofloxacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by chromatography and spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7180 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Determination of ofloxacin in tear by HPLC-ESI-MS/MS method: Comparison of ophthalmic drug release between a new mucoadhesive chitosan films and a conventional eye drop formulation in rabbit model
Byrro RMD, et al.
Journal of Pharmaceutical and Biomedical Analysis, 70(5), 544-548 (2012)
Determination of Ofloxacin in Pharmaceutical Forms by High-Performance Liquid Chromatography and Derivative Uvspectrophotometry
Carlucci G, et al.
Analytical Letters, 26(10), 2193-2201 (1993)
Simultaneous determination of ofloxacin and flavoxate hydrochloride by absorption ratio and second derivative UV spectrophotometry
Attimarad M
Journal of Basic and Clinical Pharmacy, 2(1), 53-53 (2010)
Direct determination of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin, and ciprofloxacin, in pharmaceuticals and blood serum by HPLC.
Samanidou VF, et al.
Analytical and Bioanalytical Chemistry, 375(5), 623-629 (2003)
Cécile Denève et al.
Antimicrobial agents and chemotherapy, 53(12), 5155-5162 (2009-10-07)
Recent outbreaks of Clostridium difficile infection have been related to the emergence of the NAP1/027 epidemic strain. This strain demonstrates increased virulence and resistance to the C-8-methoxyfluoroquinolones gatifloxacin and moxifloxacin. These antibiotics have been implicated as major C. difficile infection-inducing
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