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Merck

PHR1176

Tryptophan

Pharmaceutical Secondary Standard; Certified Reference Material

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A propos de cet article

Numéro CAS:
73-22-3
UNSPSC Code:
41116107
eCl@ss:
32160406
EC Number:
200-795-6
NACRES:
NA.24

Principaux documents

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SMILES string

[nH]1c2c(c(c1)CC(N)C(=O)O)cccc2

InChI key

QIVBCDIJIAJPQS-UHFFFAOYSA-N

InChI

1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. T2610000, traceable to USP 1700501

API family

tryptophan

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Tryptophan is an essential amino acid and a precursor for the synthesis of serotonin (5-HT), a neuromodulator responsible for modulating sleep and appetite regulation.

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tryptophan may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB2382 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Evolution of tryptophan and its foremost metabolites? concentrations in milk and fermented dairy products
Bertazzo A, et al.
PharmaNutrition, 4(2), 62-67 (2016)
Differential spectrophotometric determination of tyrosine and tryptophan in pharmaceutical amino acid solutions
Demeester J, et al.
Journal of Pharmaceutical Sciences, 67(5), 729-730 (1978)
Tryptophan supplementation modulates social behavior: a review
Steenbergen L, et al.
Neuroscience and Biobehavioral Reviews, 64, 346-358 (2016)
The use of carbon paste electrode in the direct voltammetric determination of tryptophan in pharmaceutical formulations
Fiorucci AR, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(5), 909-915 (2002)
Kei Hiruma et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9589-9594 (2013-05-23)
The hypersensitive response (HR) is a type of strong immune response found in plants that is accompanied by localized cell death. However, it is unclear how HR can block a broad range of pathogens with different infective modes. In this
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