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Merck

PHR1182

Papaverine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C20H21NO4 · HCl
Numéro CAS:
61-25-6
Poids moléculaire :
375.85
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823194
EC Number:
200-502-1
Beilstein/REAXYS Number:
3921435
MDL number:
MFCD00012745

Principaux documents

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InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI key

UOTMYNBWXDUBNX-UHFFFAOYSA-N

SMILES string

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. P0270000, traceable to USP 1496008

API family

papaverine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Papaverine hydrochloride is the hydrochloride salt of an opiate derivative called papaverine, a benzylisoquinoline compound. It has been found to relax smooth muscles of blood vessels and is used in the management of occlusivity and spasticity of pulmonary, coronary and peripheral arteries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Papaverine hydrochloride is used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9001 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The effect of intravenous papaverine hydrochloride on the cerebral circulation
Jayne H W, et al
The Journal of Clinical Investigation, 31(1), 111-114 (1952)
Simultaneous determination of dipyrone and papaverine in pharmaceutical formulation using PLS regression and UV spectrophotometry
do Nascimento AP, et al.
Analytical Letters, 40(5), 975-986 (2007)
Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC
Boberi B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 15-22 (1999)
Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
Abdel-Ghani NT, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(2), 373-378 (2002)
Alaa El-Gindy
Farmaco (Societa chimica italiana : 1989), 60(9), 745-753 (2005-07-19)
Three methods are developed for the simultaneous determination of diprophylline (DP), phenobarbitone (PH) and papaverine hydrochloride (PP). The chromatographic method depends on a high performance liquid chromatographic (HPLC) separation on a reversed-phase C18 column with a mobile phase consisting of
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