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Merck

PHR1204

Benzophénone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Diphenyl ketone, Diphenylmethanone, NSC 8077

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A propos de cet article

Formule linéaire :
(C6H5)2CO
Numéro CAS:
119-61-9
Poids moléculaire :
182.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823211
EC Number:
204-337-6
Beilstein/REAXYS Number:
1238185
MDL number:
MFCD00003076

Principaux documents

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InChI key

RWCCWEUUXYIKHB-UHFFFAOYSA-N

InChI

1S/C13H10O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H

SMILES string

O=C(C1=CC=CC=C1)C2=CC=CC=C2

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000647

vapor pressure

1 mmHg ( 108 °C)

API family

benzophenone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

305 °C (lit.)

mp

47-51 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzophenone is widely used in the manufacture of cosmetics and pharmaceuticals for its UV rays absorbing and fragrance retention abilities. Due to its ability to absorb ultraviolet radiations harmful in the form of UVA (320-400 nm) and UVB (290-320 nm), it is effective against skin disorders and skin cancer. It is used in the synthesis of antihistamines, hypnotics, and insecticides and is present as a potential impurity in diphenhydramine hydrochloride, phenytoin bulk powder, and phenytoin dosage forms.

Application

Benzophenone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic, spectrophotometric and polarographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3932 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Carc. 1B - STOT RE 2 Oral

target_organs

Liver,Kidney

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

280.4 °F - closed cup

flash_point_c

138 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin
Walash MI, et al.
Chemistry Central Journal, 5(1), 85-85 (2011)
Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry
Kawaguchi M, et al.
Journal of Chromatography A, 1200(2), 260-263 (2008)
Separation and simultaneous high-performance liquid chromatographic determination of benzocaine and benzyl benzoate in a pharmaceutical preparation
Gigante Barbara, et al.
Journal of Chromatography A, 549(1), 217-220 (1991)
Polarographic determination of phenytoin and benzophenone (as impurity) in pharmaceutical preparations
Razak OA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(3-4), 613-619 (2002)
Masayuki Kyomoto et al.
Biomaterials, 34(32), 7829-7839 (2013-07-31)
We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost
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