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Merck

PHR1293

Nimodipine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Nimodipine, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

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A propos de cet article

Formule empirique (notation de Hill) :
C21H26N2O7
Numéro CAS:
66085-59-4
Poids moléculaire :
418.44
NACRES:
NA.24
PubChem Substance ID:
329823284
UNSPSC Code:
41116107
EC Number:
266-127-0
MDL number:
MFCD00153848

Principaux documents

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Nom du produit

Nimodipine, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

UIAGMCDKSXEBJQ-UHFFFAOYSA-N

InChI

1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

SMILES string

COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. N0850000
traceable to USP 1463858

API family

nimodipine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Nimodipine can be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by various electrochemical and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Nimodipine is a well-known calcium antagonist and is a moderate cerebral vasodilator, in addition to being an inhibitor of cerebrovascular reactivity. It is suggested to be cytoprotective by causing a decrease in the influx of calcium into the nerve cells. It is accepted for use in the management of delayed ischaemic dysfunction and is commonlly used in the studies of brain function impairment and dementia in old age.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0583 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.
Pickard JD, et al.
BMJ (Clinical Research ed.), 298(6674), 636-642 (1989)
Nitrogen-doped graphene modified electrode for nimodipine sensing
Lei W, et al.
Sensors and Actuators B, Chemical, 212(1), 207-213 (2015)
Enantiospecific determination of nimodipine in human plasma by liquid chromatography-tandem mass spectrometry
Muck WM
Journal of Chromatography A, 712(1), 45-53 (1995)
Assay of nimodipine-an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry
Gupta VK, et al.
International Journal of Electrochemical Science, 6(1), 37-51 (2011)
The atomic absorption spectrophotometric method for indirect determination of nimodipine in tablets
Canlica M and Islimyeli S
Turkish Journal of Chemistry, 29(2), 141-146 (2005)
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