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Merck

PHR1435

Warfarin Sodium

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

3-(α-Acetonylbenzyl)-4-hydroxycoumarin sodium salt, 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin

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A propos de cet article

Formule linéaire :
C19H15O4Na
Numéro CAS:
129-06-6
Poids moléculaire :
330.31
NACRES:
NA.24
PubChem Substance ID:
329822599
UNSPSC Code:
41116107
EC Number:
204-929-4
MDL number:
MFCD00083223

Principaux documents

Voir toute la documentation
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InChI key

KYITYFHKDODNCQ-UHFFFAOYSA-M

InChI

1S/C19H16O4.Na/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22;/h2-10,15,21H,11H2,1H3;/q;+1/p-1

SMILES string

[Na].CC(=O)CC(c1ccccc1)C2=C(O)c3ccccc3OC2=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. W0100000, traceable to USP 1719000

API family

warfarin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... VKORC1(79001)

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Catégories apparentées

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Warfarin Sodium is an anticoagulant rodenticide, commonly used for the control of rodents such as rats, mice, etc. in surroundings, commercial and industrial sites.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Warfarin Sodium may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using square-wave adsorptive cathodic stripping voltammetry.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA2743 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 3 - Repr. 1B

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Colby A Nadeau et al.
Translational stroke research, 10(3), 287-297 (2018-06-28)
Intracerebral hemorrhage (ICH) causes blood-brain barrier (BBB) damage along with altered element levels in the brain. BBB permeability was quantified at 3, 7, and 14 days with Evans Blue dye after collagenase-induced ICH in rat. At peak permeability (day 3), a
Urszula Śliwińska-Hill et al.
Journal of biomolecular structure & dynamics, 37(14), 3731-3739 (2018-09-22)
The interaction between glycated human serum albumin (gHSA) and folic acid (FA) was investigated by various spectroscopic techniques, such as fluorescence, circular dichroism, UV-vis absorption spectroscopy and electrophoretic light scattering technique. These methods characterize the binding properties of an albumin-folic
Sittig's Handbook of Pesticides and Agricultural Chemicals (2014)
Analytical Methods for Therapeutic Drug Monitoring and Toxicology (2011)
Saunders Handbook of Veterinary Drugs: Small and Large Animal (2015)
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