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Merck

PHR1454

L-Arginine monohydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

(S)-(+)-Arginine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C6H14N4O2 · HCl
Numéro CAS:
1119-34-2
Poids moléculaire :
210.66
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329822614
EC Number:
214-275-1
Beilstein/REAXYS Number:
3631658
MDL number:
MFCD00064550

Principaux documents

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grade

certified reference material, pharmaceutical secondary standard

Quality Level

300

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

agency

traceable to Ph. Eur. A1271000, traceable to USP 1042601

API family

arginine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

236-230 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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Catégories apparentées

General description

Arginine Hydrochloride is a salt of arginine, which is a semi-essential amino acid. This dibasic amino acid acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Arginine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, dietary supplements and capsules by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Substrat de l′oxyde nitrique synthase qui est converti en citrulline et oxyde nitrique (NO). Induit la libération d′insuline par un mécanisme dépendant de l′oxyde nitrique.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3002 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Arginine Hydrochloride
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 44(5), 366-366 (2018)
Quantification of arginine in dietary supplement tablets and capsules by silica gel high-performance thin-layer chromatography with visible mode densitometry
Hess B and Sherma J
Acta Chromatographica , 60-69 (2004)
Nivaldo Ribeiro Villela et al.
Journal of translational medicine, 12, 232-232 (2014-08-26)
Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. This paper investigates the role of the nitric oxide
Jenna Gallie et al.
PLoS biology, 13(3), e1002109-e1002109 (2015-03-13)
Phenotype switching is commonly observed in nature. This prevalence has allowed the elucidation of a number of underlying molecular mechanisms. However, little is known about how phenotypic switches arise and function in their early evolutionary stages. The first opportunity to
X Zheng et al.
Journal of dental research, 94(2), 344-353 (2014-12-06)
Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within the dental plaque. Fluoride is a widely used anticaries agent, which promotes tooth hard-tissue remineralization and suppresses bacterial activities. Recent clinical trials have
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