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Merck

PHR1462

Creatinine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Creatinine, 2-Amino-1-methyl-2-imidazolin-4-one, 2-Imino-1-methylimidazolidin-4-one, 2-Imino-N-methylhydantoin

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A propos de cet article

Formule empirique (notation de Hill) :
C4H7N3O
Numéro CAS:
60-27-5
Poids moléculaire :
113.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823394
EC Number:
200-466-7
Beilstein/REAXYS Number:
112061
MDL number:
MFCD00059730

Principaux documents

Voir toute la documentation
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InChI key

DDRJAANPRJIHGJ-UHFFFAOYSA-N

InChI

1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)

SMILES string

CN1CC(=O)N=C1N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1150353

API family

creatinine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

295 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Creatinine is a by-product produced during the metabolism of creatine phosphate in muscle. It is excreted through urine, and serum creatinine level is most common indicator of renal health.

Application

Creatinine may be used as a pharmaceutical reference standard for the determination of the analyte in biological fluids by spectrophotometry, and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3010 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

554.0 °F - closed cup

flash_point_c

290 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Creatinine determined by high-performance liquid chromatography.
Ambrose RT, et al.
Clinical Chemistry, 29(2), 256-259 (1983)
A simplified method for HPLC determination of creatinine in mouse serum
Yuen PST, et al.
American Journal of Physiology: Renal Physiology, 286(6), F1116-F1119 (2004)
Improved HPLC method for the simultaneous determination of allantoin, uric acid and creatinine in cattle urine
George SK
Journal of Chromatography. B, Biomedical Sciences and Applications, 832(1), 134-137 (2006)
Creatinine
Clinical Veterinary Advisor, 615-615 (2013)
7.4 - Tubular Reabsorption and Secretion
Quantitative Human Physiology: An Introduction, 645-655 (2012)
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