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Merck

PHR1530

Acetaminophen Related Compound D

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Acetanilide, N-Phenylacetamide

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A propos de cet article

Formule linéaire :
CH3CONHC6H5
Numéro CAS:
103-84-4
Poids moléculaire :
135.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823442
EC Number:
203-150-7
Beilstein/REAXYS Number:
606468
MDL number:
MFCD00008674

Principaux documents

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InChI key

FZERHIULMFGESH-UHFFFAOYSA-N

InChI

1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)

SMILES string

CC(=O)Nc1ccccc1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1003042

vapor density

4.65 (vs air)

vapor pressure

1 mmHg ( 114 °C)

description

API family: acetaminophen

API family

acetaminophen, paracetamol

CofA

current certificate can be downloaded

autoignition temp.

1004 °F

packaging

pkg of 200 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

304 °C (lit.)

Quality Level

300

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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Catégories apparentées

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol.

Application

This pharmaceutical secondary standard can also be used as follows:

  • Detection and quantification of paracetamol, phenylephrine hydrochloride, and paracetamol impurities in pharmaceutical formulations using four chemometric-based spectrophotometric methods
  • Simultaneous determination of paracetamol and phenylephrine hydrochloride in the presence of paracetamol-related impurities using capillary zone electrophoresis (CZE) in their combined tablet forms

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAA3648 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

321.8 °F - closed cup

flash_point_c

161 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Capillary zone electrophoresis as a quality assessment tool of paracetamol and phenylephrine hydrochloride in presence of paracetamol impurities
FARID J, et al.
Turkish Journal of Chemistry, 46, 217-223 (2022)
Octavian Călinescu et al.
Journal of chromatographic science, 50(4), 335-342 (2012-03-13)
Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil
Fabrice Gritti et al.
Journal of chromatography. A, 1355, 179-192 (2014-07-09)
The mass transfer mechanism in four prototype columns (2.1 and 3.0×50mm, 2.1 and 3.0×100mm) packed with 1.9μm fully porous Titan-C18 particles was investigated by using two previously reported home-made protocols. The first one was used to measure the eddy dispersion
Naoki Aizawa et al.
Neurourology and urodynamics, 34(4), 368-374 (2014-02-18)
We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a β3-adrenoceptor agonist, and oxybutynin, an antimuscarinic agent, can affect the SAAs in such condition. Twenty-nine female Sprague-Dawley
Hassan A Alhazmi et al.
Journal of pharmaceutical and biomedical analysis, 107, 311-317 (2015-02-02)
In this work, the behavior of several metal ions with different globular proteins was investigated by affinity capillary electrophoresis. Screening was conducted by applying a proper rinsing protocol developed by our group. The use of 0.1M EDTA in the rinsing
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