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Merck

PHR1796

Imipenem

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Imipenem monohydrate, (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate

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A propos de cet article

Formule empirique (notation de Hill) :
C12H17N3O4S · H2O
Numéro CAS:
74431-23-5
Poids moléculaire :
317.36
NACRES:
NA.24
PubChem Substance ID:
329823620
UNSPSC Code:
41116107
EC Number:
264-734-5
MDL number:
MFCD09753321

Principaux documents

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Nom du produit

Imipenem, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

SMILES string

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. I0090000
traceable to USP 1337809

API family

imipenem

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

storage temp.

-10 to -25°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Imipenem may be used as a pharmaceutical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations by various analytical techniques.

Biochem/physiol Actions

Imipenem monohydrate is a broad spectrum B-lactam antibiotic.
Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Imipenem belongs to the class of carbapenems, a beta-lactam antibiotic, effective against aerobic and anaerobic bacteria. Carbapenems act by inhibiting the peptidoglycan synthesis involved in bacterial cell wall formation, thus causing the death of the target microorganism.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0262 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Lipika Singhal et al.
Microbial drug resistance (Larchmont, N.Y.), 24(8), 1082-1088 (2018-02-07)
With the increasing threat of multidrug-resistant organisms, such as Acinetobacter baumannii, the polymyxin class of drugs (colistin and polymyxin B) has become popular in clinical practice. A better understanding of antimicrobial susceptibility testing methods for colistin and polymyxin B is
Stability-indicating HPLC method development and validation for simultane-ous determination of cilastatin and imipenem in pharmaceutical dosage forms
Kishore MS and Rambabu C
International Journal of Research in Pharmaceutical Sciences, 8(4), 560-567 (2017)
Determination of imipenem in plasma by high-performance liquid chromatography for pharmacokinetic studies in patients
Garcia-Capdevila L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 692(1), 127- 132 (1997)
Juan R Mella et al.
Shock (Augusta, Ga.), 52(1), 61-66 (2018-08-11)
Substance P (SP) is a neuropeptide that contributes to a proinflammatory state by binding to the neurokinin 1 receptor (NK-1R). Limiting this interaction has been shown to attenuate the acute inflammation. Our hypothesis was that NK-1R activation would contribute to
Zainab Edoo et al.
Scientific reports, 7(1), 9136-9136 (2017-08-24)
β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the
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