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Merck

Y0000507

Chlorpromazine impurity A

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Chlorpromazine sulfoxide, 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1- amine S-oxide

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A propos de cet article

Formule empirique (notation de Hill) :
C17H19ClN2OS
Numéro CAS:
Poids moléculaire :
334.86
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

pharmaceutical primary standard

API family

chlorpromazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[S+]1(c2c(cc(cc2)Cl)N(c3c1cccc3)CCCN(C)C)[O-]

InChI

1S/C17H19ClN2OS/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)22(21)17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

InChI key

QEPPAOXKZOTMPM-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorpromazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.


Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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M Nakano et al.
Biochemical and biophysical research communications, 130(3), 952-956 (1985-08-15)
Chemiluminescence in visible region was detected, during peroxidase-catalyzed oxidation of chlorpromazine at pH7.5 (but not at pH4.25) or of propericiazine, both at pH7.5 and at pH4.25. Red colored intermediates, cation radicals, were produced and decayed in all enzymatic systems used.
P K Yeung et al.
The Journal of pharmacology and experimental therapeutics, 226(3), 833-838 (1983-09-01)
Antibody specific for chlorpromazine sulfoxide (CPZSO) was produced in rabbits immunized with a hapten-bovine serum albumin conjugate, which was prepared by linking the 10-alkyl side chain of CPZSO to the protein molecule via a 2-carbon bridge. A simple radioimmunoassay was
Free radical production by chlorpromazine sulfoxide, an ESR spin-trapping and flash photolysis study.
G R Buettner et al.
Photochemistry and photobiology, 44(1), 5-10 (1986-07-01)