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Merck

Y0000769

Promethazine impurity D

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(2RS)-N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine S-oxide, Promethazine 5-sulfoxide

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A propos de cet article

Formule empirique (notation de Hill) :
C17H20N2OS
Numéro CAS:
7640-51-9
Poids moléculaire :
300.42
UNSPSC Code:
41116107
NACRES:
NA.24

Principaux documents

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Nom du produit

Promethazine impurity D, European Pharmacopoeia (EP) Reference Standard

SMILES string

[S]1(=O)c2c(cccc2)N(c3c1cccc3)CC(N(C)C)C

InChI

1S/C17H20N2OS/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)21(20)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

InChI key

OWTCLFIFAFHQIX-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

promethazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Catégories apparentées

Application

Promethazine impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Ronald J Peters et al.
Journal of drug education, 33(4), 415-425 (2004-07-09)
In the current study, we used a qualitative approach to investigate relevant beliefs and norms associated with codeine and promethazine hydrochloride cough syrup (CPHCS) consumption, initiation, and perceived addiction among 48 alternative school students who identified themselves as current CPHCS
S R Vanapalli et al.
Journal of chromatographic science, 39(2), 70-72 (2001-03-14)
A new assay method has been developed for the quantitation of promethazine (PMZ) with a sensitivity and reproducibility as good as any previously reported method. This method is also capable of quantitatively determining three metabolites of PMZ (monodemethylated, sulphoxidated, and
L Galzigna et al.
Free radical biology & medicine, 20(6), 807-811 (1996-01-01)
Promethazine sulfoxide was obtained with a quantitative yield in a horse radish peroxidase-catalyzed reaction of promethazine and hydrogen peroxide and was also prepared by direct chemical synthesis. The enzymatic sulfoxidation of promethazine was studied in vitro as a function of
L Galzigna et al.
Free radical research, 27(5), 501-504 (1998-03-28)
Lactoperoxidase, when incubated with increasing amounts of promethazine (P) and promethazine sulfoxide (PO) catalyzes the formation of promethazine sulfoxide accompanied by oxygen consumption. An intermediate radical of PO can be detected by electron spin resonance (ESR). Catalase or superoxide dismutase
Xufei Li et al.
Se pu = Chinese journal of chromatography, 30(9), 938-942 (2013-01-05)
Based on the phenomenon that each of chlorpromazine (CPZ), promethazine (PMZ), chlorpromazine sulfoxide (CPZSO) and promethazine sulfoxide (PMZSO) could enhance the electrochemiluminescence (ECL) intensity of tris(2,2'-bipyridyl) ruthenium, a novel and sensitive method was proposed for the simultaneous determination of CPZ

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