G5417
Glycine
Synonyme(s) :
Acide aminoacétique, Acide aminoéthanoïque, Glycocolle
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A propos de cet article
Formule linéaire :
NH2CH2COOH
Numéro CAS:
Poids moléculaire :
75.07
UNSPSC Code:
12352209
NACRES:
NA.25
eCl@ss:
32160406
EC Number:
200-272-2
Beilstein/REAXYS Number:
635782
MDL number:
Service technique
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Laissez-nous vous aiderbiological source
non-animal source
Quality Level
assay
≥98.5%
form
crystalline powder
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, heavy metals, trace metals, residual solvents, tested
pH
5.9-6.4
pKa (25 °C)
(1) 2.35, (2) 9.60, 2.35
mp
240 °C (dec.) (lit.)
solubility
H2O: 100 mg/mL
UV absorption
λ: 260 nm Amax: ≤0.04, λ: 260 nm Amax: -0.006, λ: 280 nm Amax: ≤0.04, λ: 280 nm Amax: -0.003
suitability
suitable for manufacturing use
application(s)
pharmaceutical (small molecule)
foreign activity
cytotoxicity, tested
SMILES string
NCC(O)=O
InChI
1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI key
DHMQDGOQFOQNFH-UHFFFAOYSA-N
Gene Information
rat ... Grin2a(24409)
General description
Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request the documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.
Application
Glycine is a non-essential amino acid. It is the simplest of the amino acids and plays various roles in biology. It is structurally unique among the biological amino acids in that it does not have an asymmetric center, and thus is not chiral. It is commonly used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Biochem/physiol Actions
Neurotransmetteur inhibiteur de la moelle épinière, régulateur allostérique des récepteurs du NMDA.
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
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Classe de stockage
13 - Non Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Zoé Husson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)
The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory
Bethany L Johnson-Kerner et al.
Human molecular genetics, 24(5), 1420-1431 (2014-11-16)
Giant axonal neuropathy (GAN) is a progressive neurodegenerative disease caused by autosomal recessive mutations in the GAN gene resulting in a loss of a ubiquitously expressed protein, gigaxonin. Gene replacement therapy is a promising strategy for treatment of the disease;