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Merck

1019701

USP

Amiloride hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Amiloride hydrochloride dihydrate, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate

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A propos de cet article

Formule empirique (notation de Hill) :
C6H8ClN7O · HCl · 2H2O
Numéro CAS:
17440-83-4
Poids moléculaire :
302.12
MDL number:
MFCD11046655
UNSPSC Code:
41116107
NACRES:
NA.24

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Nom du produit

Amiloride hydrochloride, United States Pharmacopeia (USP) Reference Standard

SMILES string

Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O

InChI

1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

InChI key

LTKVFMLMEYCWMK-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

amiloride

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

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Catégories apparentées

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets
  • Amiloride Hydrochloride Tablets

General description

Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.

Other Notes

Sales restrictions may apply.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Zebrafish Na(+)/H(+) exchanger 3b (zNHE3b) is highly expressed in the apical membrane of ionocytes where Na(+) is absorbed from ion-poor fresh water against a concentration gradient. Much in vivo data indicated that zNHE3b is involved in Na(+) absorption but not
Juraj Rievaj et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(4), G303-G313 (2013-06-15)
Intestinal calcium (Ca²⁺) absorption occurs via paracellular and transcellular pathways. Although the transcellular route has been extensively studied, mechanisms mediating paracellular absorption are largely unexplored. Unlike passive diffusion, secondarily active paracellular Ca²⁺ uptake occurs against an electrochemical gradient with water
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