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About This Item
Formule linéaire :
(CH3)3N+CH2CH(OH)CH2COO-
Numéro CAS:
Poids moléculaire :
161.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4292315
Nom du produit
Levocarnitine, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
SMILES string
C[N+](C)(C)C[C@H](O)CC([O-])=O
InChI key
PHIQHXFUZVPYII-ZCFIWIBFSA-N
grade
pharmaceutical primary standard
API family
levocarnitine
manufacturer/tradename
USP
mp
197-212 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Levocarnitine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
Also, for use with USP monographs such as:
- Levocarnitine Tablets
- Levocarnitine Injection
- Levocarnitine Oral Solution
Biochem/physiol Actions
Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Allan Evans
American journal of kidney diseases : the official journal of the National Kidney Foundation, 41(4 Suppl 4), S13-S26 (2003-05-17)
Among the homeostatic processes controlling the endogenous L-carnitine pool in humans, the kidney has a vital role through extensive and adaptive tubular reabsorption. Kidney disease can lead to disturbances in L-carnitine homeostasis, and long-term hemodialysis therapy can lead to a
P D Pion et al.
The Veterinary clinics of North America. Small animal practice, 28(6), 1495-1514 (1999-03-31)
In this article, the current state of knowledge of the potential role of taurine and L-carnitine deficiency and supplementation in the genesis and management of cardiovascular disease in dogs is presented. There is limited direct evidence to support the recommendations
Marieke G Schooneman et al.
Biochimica et biophysica acta, 1841(7), 987-994 (2014-04-22)
Acylcarnitines have been linked to obesity-induced insulin resistance. However the majority of these studies have focused on acylcarnitines in plasma. It is currently unclear to what extent plasma levels of acylcarnitines reflect tissue acylcarnitine metabolism. We investigated the correlation of
Reese H Clark et al.
Pediatrics, 134(1), e37-e46 (2014-06-11)
To describe the influence that gestational age and chronological age have on amino acid and acylcarnitine profiles in an at-risk population of premature infants. Metabolic profiles (15 amino acids and 35 acylcarnitines) were obtained by using standard newborn techniques on
Yasuro Furuichi et al.
Biochimica et biophysica acta, 1837(10), 1699-1706 (2014-06-03)
Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine, acts as an acceptor of excess acetyl-CoA, a potent inhibitor of pyruvate dehydrogenase. Here, we provide a new
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