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Merck

KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonymes:
ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(3757) Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(16511) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Rat(117018) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Zebrafish(405763) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • naked mole-rat(101711977) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic cat(101081621) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Horse(100064000) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Domestic Rabbit(100009242) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • dog(403761) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic guinea pig(100135563) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • cow(539971) potassium voltage-gated channel, subfamily H (eag-related), member 2

Custom & Knockdown Gene Products

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Sotalol hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human
Glyburide, meets USP testing specifications,
Espèce(s)
rat, human
(±)-Sotalol hydrochloride, ≥98% (TLC), powder,
Espèce(s)
human
Glybenclamide, ≥99% (HPLC),
Espèce(s)
rat, human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-Potassium Channel KV11.1 (HERG) Extracellular-FITC antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
human
Application
flow cytometry
immunocytochemistry
Anti-Potassium Channel HERG Antibody, CT, Chemicon®, from rabbit,
Espèces réactives
human
Application
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-KCNH2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-Potassium Channel ERG1 Antibody, CT, Chemicon®, from rabbit,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
human
Application
flow cytometry
immunocytochemistry

western blot

Small Molecule - Blocker

Numéro du produit
Description
Espèce(s)
Ibutilide hemifumarate salt, ≥98% (HPLC),
Espèce(s)
human
Dofetilide, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Dofetilide, ≥98% (HPLC),
Espèce(s)
human
Amiodarone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Ibutilide fumarate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 885.23 ([(C20H36N2O3S)2 . C4H4O4]),
Espèce(s)
human

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
Loratadine, ≥98% (HPLC), powder,
Espèce(s)
rat, human
Terfenadine, ,
Espèce(s)
mouse, rat, human
Cocaine free base, ,
Espèce(s)
mouse, rat, human
Pimozide, ,
Espèce(s)
human, mouse, rat
Haloperidol, powder,
Espèce(s)
human, rat

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human KCNH2,
Espèce(s)
human