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07-1450-I Anti-Beta Pix, SH3 Domain Antibody

Detect Beta Pix using this Anti-Beta Pix antibody, SH3 Domain validated for use in western blotting.

Anti-Beta Pix, SH3 Domain Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: ARHGEF7, COOL1, P85SPR, PAK3BP, PIXB UniProt Number: Q14155
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07-1450-I
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1450-I
      Replaces07-1450
      DescriptionAnti-Beta Pix, SH3 Domain Antibody
      Alternate Names
      • Rho guanine nucleotide exchange factor 7
      • Beta-Pix
      • COOL-1
      • PAK-interacting exchange factor beta
      • p85
      Background InformationBeta-Pix (ARHGEF7, βPix, COOL) is a Rho guanine nucleotide exchange factor (GEF). Beta-Pix is a p21-activated protein kinase (PAK)-interacting exchange factor (Pix, COOL, p85SPR) that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. The variants of Beta-Pix isoforms exhibit different tissue distributions. Beta-Pix-a is expressed ubiquitously in all the tissues examined, and other isoforms are expressed mainly in the central nervous system. PAK, a Ser/Thr kinase, is an important mediator of Rho family activity interacts with Beta-Pix at the SH3 domain of Beta-Pix though its proline rich region. This interaction is thought to affect the GTP hydrolysis rate of Rac and Cdc42.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Beta Pix using this Anti-Beta Pix antibody, SH3 Domain validated for use in western blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected Beta-Pix, SH3 Domain in 10 µg of PC-12 cell lysate.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the SH3 domain of human Beta-Pix, SH3 Domain.
      EpitopeSH3 domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARHGEF7
      • COOL1
      • P85SPR
      • PAK3BP
      • PIXB
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~80 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Beta-Pix, SH3 Domain in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-1450-I 04053252958137

      Documentation

      Anti-Beta Pix, SH3 Domain Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Beta Pix, SH3 Domain Antibody Certificates of Analysis

      TitleLot Number
      Anti-Beta Pix, SH3 Domain - Q2388146 Q2388146
      Anti-Beta Pix, SH3 Domain - 3267308 3267308
      Anti-Beta Pix, SH3 Domain - 3425570 3425570
      Anti-Beta Pix, SH3 Domain - 3597304 3597304
      Anti-Beta Pix, SH3 Domain - 4070114 4070114
      Anti-Beta Pix, SH3 Domain - 4134971 4134971
      Anti-Beta Pix, SH3 Domain - 4198946 4198946
      Anti-Beta Pix, SH3 Domain -2505110 2505110
      Anti-Beta Pix, SH3 Domain -2570242 2570242
      Anti-Beta Pix, SH3 Domain -2608851 2608851
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