M-132
N-メチル-N-(トリメチルシリル)トリフルオロアセトアミド
ampule of 10 × 1.2 mL, analytical standard, Cerilliant®
別名:
N-トリメチルシリル-N-メチルトリフルオロアセトアミド, MSTFA
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この商品について
化学式:
CF3CON(CH3)Si(CH3)3
CAS番号:
分子量:
199.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
InChI key
MSPCIZMDDUQPGJ-UHFFFAOYSA-N
InChI
1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
SMILES string
CN(C(=O)C(F)(F)F)[Si](C)(C)C
grade
analytical standard
vapor density
>1 (vs air)
vapor pressure
8.8 mmHg ( 27 °C)
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
packaging
ampule of 10 × 1.2 mL
manufacturer/tradename
Cerilliant®
technique(s)
gas chromatography (GC): suitable
refractive index
n20/D 1.38 (lit.)
bp
130-132 °C (lit.)
density
1.075 g/mL at 25 °C (lit.)
application(s)
forensics and toxicology
format
neat
storage temp.
−20°C
Quality Level
General description
MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.
Application
MSTFA reagent may be used as a derivatizing agent in the following:
- Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2), and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
- Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).
Features and Benefits
- Very volatile of TMS-acetamides.
- More volatile than BSA or BSTFA but with similar silylation strength.
- Useful in the analysis of volatile trace materials.
- Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
3 - Flammable liquids
wgk
WGK 3
flash_point_f
77.0 °F - closed cup
flash_point_c
25 °C - closed cup
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
第4類:引火性液体 + 第二石油類 + 危険等級III + 非水溶性液体
fsl
M-132-10X1.2ML:
jan
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry
Sebok A, et al.
Talanta, 76(3), 642-650 (2008)
The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography?mass spectrometry based metabolomics
Khakimov B, et al.
Analytical and Bioanalytical Chemistry, 405(3), 9193-9205 (2013)
Analysis of trenbolone acetate metabolites and melengestrol in environmental matrices using gas chromatography--tandem mass spectrometry
Parker AJ, et al.
Talanta, 99(3), 238-246 (2012)
Stina K Lien et al.
Journal of chromatography. A, 1247, 118-124 (2012-06-15)
GC-MS analysis of silylated metabolites is a sensitive method that covers important metabolite groups such as sugars, amino acids and non-amino organic acids, and it has become one of the most important analytical methods for exploring the metabolome. Absolute quantitative
Guro Forsdahl et al.
Journal of separation science, 27(1-2), 110-114 (2004-09-01)
A sensitive method for the quantification of free salbutamol in human urine is described. Sample clean up is performed using SPE on a mixed phase extraction column. Derivatisation is performed with N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA) and the extract is analysed by GC-MS.
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