1.08212
Parteck® PLX 188 (Poloxamer 188)
(stabilized with 70ppm BHT), EMPROVE® ESSENTIAL, Ph. Eur., ChP, NF
別名:
Poloxamer 188
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
biological source
synthetic
agency
ChP, NF, Ph. Eur.
product line
EMPROVE® ESSENTIAL
bp
>150 °C
mp
55 °C
bulk density
1050 kg/m3
storage temp.
2-25°C
Quality Level
General description
With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Application
Parteck® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.
Features and Benefits
- Hydrophilic, water-soluble tablet lubrication
- Improved dissolution rates for poorly soluble DCS class IIa molecules
- Specified particle size distribution optimized for solid application performance
- Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
資料
Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.
関連コンテンツ
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 1.08212.9025 | 04061841048671 |
| 1.08212.0001 | 04061841048640 |
| 1.08212.0500 | 04061841048657 |
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