239764
Cycloheximide, High Purity
Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes.
別名:
Cycloheximide, High Purity
製品名
Cycloheximide, High Purity, Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes.
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
assay
≥98% (HPLC)
form
solid
potency
3.4 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
chloroform: soluble
ethanol: soluble
methanol: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
Primary Target
hFKBP12
hFKBP12
Disclaimer
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
General description
Antifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005 ), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952 ). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739 ).
Other Notes
Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Cotter, T.G., et al. 1992. Anticancer Res.12, 773.
Takano, Y.S., et al. 1991. J. Pathol.163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Lu, Q., et al. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Cotter, T.G., et al. 1992. Anticancer Res.12, 773.
Takano, Y.S., et al. 1991. J. Pathol.163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Ashley N Stewart et al.
Biochemistry, 58(6), 727-741 (2018-12-20)
C1q/TNF-related protein 12 (CTRP12) is a secreted regulator of glucose and lipid metabolism. It circulates in plasma as a full-length protein or as a cleaved isoform generated by furin/PCSK3 cleavage. These isoforms preferentially activate different signaling pathways, and their ratio
Yuan-Lin Kang et al.
bioRxiv : the preprint server for biology (2020-06-09)
Virus entry is a multistep process. It initiates when the virus attaches to the host cell and ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert analogous subcellular mechanisms and use similar trafficking pathways for successful
Yuan-Lin Kang et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20803-20813 (2020-08-09)
Virus entry is a multistep process. It initiates when the virus attaches to the host cell and ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert analogous subcellular mechanisms and use similar trafficking pathways for successful
Dirk Brehmer et al.
Molecular cancer therapeutics, 20(12), 2317-2328 (2021-09-30)
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular proliferation. Dysregulation of PRMT5 is associated with clinical
Cai Han et al.
STAR protocols, 3(1), 101037-101037 (2022-01-04)
Micropeptides are emerging as important regulators of various cellular processes. Long non-coding RNAs (lncRNAs) serve as a source of micropeptide-encoding small reading frames. The techniques to detect micropeptides or translating lncRNAs, such as mass spectrometry and ribosome profiling, are sophisticated
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