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27102

クエン酸 一水和物

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

別名:

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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この商品について

化学式:
HOC(COOH)(CH2COOH)2 · H2O
CAS番号:
5949-29-1
分子量:
210.14
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
57648219
EC Number:
201-069-1
Beilstein/REAXYS Number:
4018641
MDL number:
MFCD00149972
Assay:
99.5-100.5% (based on anhydrous substance)
Form:
grit
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grade

puriss.

Quality Level

200

assay

99.5-100.5% (based on anhydrous substance)

form

grit

quality

meets analytical specification of Ph. Eur., BP, USP, E330

impurities

residual solvents, complies, ≤0.0005% heavy metals (as Pb), 7.5-8.8% water (Karl Fischer)

ign. residue

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤50 mg/kg, oxalate (as oxalic acid): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Ca: ≤200 mg/kg, Cu: ≤10 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, Pb: ≤1 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution, complies for identity (IR), complies for reaction against H2SO4

functional group

carboxylic acid

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

保管分類

11 - Combustible Solids

flash_point_f

345.0 °F - closed cup

flash_point_c

173.9 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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試験成績書（COA）

Lot/Batch Number
BCCM7252
BCCK3277
BCCH5300
BCCG2090
BCCD2310

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S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.
Apelblat A.
The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)
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