クエン酸一水和物

Name: クエン酸 一水和物
Brand: SIAL

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

別名:

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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この商品について

化学式:

HOC(COOH)(CH₂COOH)₂ · H₂O

CAS番号:

5949-29-1

分子量:

210.14

UNSPSC Code:

12352100

NACRES:

NA.21

PubChem Substance ID:

57648219

EC Number:

201-069-1

Beilstein/REAXYS Number:

4018641

MDL number:

MFCD00149972

Assay:

99.5-100.5% (based on anhydrous substance)

Form:

grit

主要文書

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製品名

クエン酸一水和物, puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

grade

puriss.

assay

99.5-100.5% (based on anhydrous substance)

form

grit

quality

meets analytical specification of Ph. Eur., BP, USP, E330

impurities

residual solvents, complies
≤0.0005% heavy metals (as Pb)
7.5-8.8% water (Karl Fischer)

ign. residue

≤0.05% (as SO₄)

pKa

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl^-): ≤50 mg/kg
oxalate (as oxalic acid): ≤100 mg/kg
sulfate (SO₄^2-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg
Ca: ≤200 mg/kg
Cu: ≤10 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤10 mg/kg

suitability

complies for appearance of solution
complies for identity (IR)
complies for reaction against H₂SO₄

functional group

carboxylic acid

Quality Level

200

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Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be Δ_solH_m(298.15K, m = 0.0203molkg^-1) = (29061 ± 123)Jmol^-1

pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

345.0 °F - closed cup

flash_point_c

173.9 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

27102-6X1KG-R: + 27102-BULK-R: + 27102-1KG-R: + 27102-25KG-R: + 27102-VAR-R: + 27102-2.5KG-R: + 27102-6X2.5KG-R:

jan

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Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.

S Massberg et al.

The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)

Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.

Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.

Sandra U Schilling et al.

International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)

Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem

Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.

Apelblat A.

The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)

Impact of Sn/F Pre-Treatments on the Durability of Protective Coatings against Dentine Erosion/Abrasion.

Carolina Ganss et al.

PloS one, 10(6), e0123889-e0123889 (2015-06-16)

For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)

Effect of grinding intensity and pelleting of the diet on indoor particulate matter concentrations and growth performance of weanling pigs.

T Ulens et al.

Journal of animal science, 93(2), 627-636 (2014-12-31)

This study evaluated the effect of feed form and grinding intensity of the pig diet and the interaction between both on the particulate matter (PM) concentrations inside a pig nursery and the growth performances of weanling pigs. Four diets were

クエン酸 一水和物

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

サイズを選択してください

この商品について

主要文書

特性

製品名

InChI key

InChI

SMILES string

grade

assay

form

quality

impurities

ign. residue

pKa

anion traces

cation traces

suitability

functional group

Quality Level

関連するカテゴリー

詳細

Application

General description

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

27102-6X1KG-R: + 27102-BULK-R: + 27102-1KG-R: + 27102-25KG-R: + 27102-VAR-R: + 27102-2.5KG-R: + 27102-6X2.5KG-R:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

テクニカルサービス

クエン酸一水和物