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Merck

34392

メチルジブロモグルタロニトリル

analytical standard

別名:

1,2-ジブロモ-2,4-ジシアノブタン, 1-ブロモ-1-(ブロモメチル)-1,3-プロパンジカルボニトリル, 2-ブロモ-2-(ブロモメチル)グルタロニトリル

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この商品について

実験式(ヒル表記法):
C6H6Br2N2
CAS番号:
分子量:
265.93
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
EC Number:
252-681-0
MDL number:
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grade

analytical standard

Quality Level

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

51-55 °C

application(s)

environmental

format

neat

storage temp.

2-8°C

SMILES string

BrCC(Br)(CCC#N)C#N

InChI

1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2

InChI key

DHVLDKHFGIVEIP-UHFFFAOYSA-N

General description

Methyldibromoglutaronitrile (MDBGN) is a bromine-containing preservative and a clinically significant allergen as investigated from animal/human clinical studies.
Methyldibromoglutaronitrile can be generally used as a preservative in the cosmetic industry for many skin care products.

Application

Methyldibromoglutaronitrile may be used as an analytical reference standard for the quantification of the analyte in cosmetic products using ultra performance liquid chromatography (UPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) and gas chromatography followed by mass spectrometry technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

CorrosionExclamation mark

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

保管分類

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Charlotte Gotthard Mortz et al.
Current opinion in allergy and clinical immunology, 8(5), 428-432 (2008-09-05)
To give selected new information on contact allergy and allergic contact dermatitis with focus on diagnostic procedures and pitfalls. Recent studies dealing with common contact allergens have improved our understanding of the relationship between positive patch tests and the clinical
Patch testing with methyldibromoglutaronitrile
Geier J, et al.
American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 11, 207-212 (2000)
Annice Heratizadeh et al.
Contact dermatitis, 62(6), 330-337 (2010-06-19)
While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products. The objective of this study was to find a
A C De Groot et al.
Journal of the American Academy of Dermatology, 35(5 Pt 1), 743-747 (1996-11-01)
Euxyl K 400 is a preservative system for cosmetics and toiletries that contains phenoxyethanol and methyldibromoglutaronitrile in a 4:1 ratio. In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4
Axel Schnuch et al.
Contact dermatitis, 56(6), 331-337 (2007-06-20)
Although genetic factors probably account for differences in susceptibility to contact allergy, they have not yet been identified, partly due to an insufficient understanding of 'susceptibility'. Regarding polysensitization (PS) as a sign of increased susceptibility, we studied the relationship between

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