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Merck

86541

プロピオン酸テストステロン

tested according to Ph. Eur.

別名:

17β-ヒドロキシ-4-アンドロステン-3-オン 17-プロピオナート, 17β-プロピオニルオキシ-4-アンドロステン-3-オン, 4-アンドロステン-17β-オール-3-オン 17-プロピオナート

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この商品について

実験式（ヒル表記法）:
C22H32O3
CAS番号:
57-85-2
分子量:
344.49
UNSPSC Code:
12352211
NACRES:
NA.21
PubChem Substance ID:
329769470
EC Number:
200-351-1
Beilstein/REAXYS Number:
3221760
MDL number:
MFCD00003653

主要文書

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InChI key

PDMMFKSKQVNJMI-BLQWBTBKSA-N

InChI

1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])OC(=O)CC

Gene Information

human ... AR(367), CYP17A1(1586)
rat ... Ar(24208)

agency

tested according to Ph. Eur.

form

solid

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

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関連するカテゴリー

General description

Testosterone propionate is the esterified form of testosterone that is most commonly used in clinical applications for the treatment of hypogonadism, oligospermia, and impotence. 17β-hydroxyl group of propionate is esterified to get this form. It is a fast and short-acting form when compared to enanthate and cypionate forms, which are long-acting esters more commonly used in androgen replacement therapies.

Application

Testosterone propionate has been used:
  • to determine the effect of testosterone on the uptake of certain amino acids, such as isoleucine and α-(methylamino)isobutyric acid
  • in a study to understand the effects of testosterone on brain aromatase activity in neonatal quail brain
  • for testosterone treatment of Celf1 knockout mice in a study to investigate the upregulation of aromatase activity in association with hypogonadism
  • to investigate the ontogeny of aromatase-expressing neurons in Japanese quail brain
  • to study the effects of in vivo administration of testosterone propionate on fluid reabsorption in the efferent ducts of rat.

Biochem/physiol Actions

Testosterone is the major circulating androgen in men and is mainly produced by the testis. A small amount is secreted by the adrenal gland. It is produced from cholesterol in the Leydig cells. Testosterone is metabolized to dihydrotestosterone, a potent androgen that associates with a cytoplasmic receptor protein, to form a complex. This complex is activated and transported into the nucleus, where it triggers several biological responses. It mainly participates in the development of the male phenotype during embryogenesis and at puberty.

Other Notes

Sales restrictions may apply

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1A

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

86541-BULK: + 86541-5G: + 86541-VAR:

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
BCCN6480
BCCL7068
BCCK7443
BCCJ3672
BCCG4695

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文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Clinical Use and Abuse of Androgens and Antiandrogens
Becker KL., (eds.)
Principles and Practice of Endocrinology and Metabolism, 957-957 null
M Fujioka et al.
The Journal of clinical endocrinology and metabolism, 63(6), 1361-1364 (1986-12-01)
The pharmacokinetic characteristics of testosterone propionate were studied in normal men after a single im dose of 25 mg testosterone propionate-19,19,19-d3. Plasma levels of testosterone propionate-19,19,19-d3, its active metabolite testosterone-19,19,19-d3, and endogenous testosterone were measured by gas chromatography-mass spectrometry. Testosterone
Francois Mougeot et al.
Proceedings. Biological sciences, 276(1659), 1093-1100 (2009-01-09)
Extravagant ornaments evolved to advertise their bearers' quality, the honesty of the signal being ensured by the cost paid to produce or maintain it. The oxidation handicap hypothesis (OHH) proposes that a main cost of testosterone-dependent ornamentation is oxidative stress
J D Wilson et al.
Human genetics, 58(1), 78-84 (1981-01-01)
Male and female embryos develop in an identical fashion during the initial portion of gestation. If the indifferent gonad differentiates into an ovary (or if no gonad is present), a female phenotype is formed. Male phenotypic differentiation, however, requires the
L A Hansen et al.
International journal of andrology, 20(5), 265-273 (2005-09-01)
The regulation by oestradiol and testosterone of fluid reabsorption in the efferent ducts of the rat was investigated by determining the effects of administering the hormones and their antagonists. Untreated rats were compared to animals treated for 7 days with
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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