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この商品について
実験式(ヒル表記法):
C17H19ClN2S · HCl
CAS番号:
分子量:
355.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3779989
製品名
クロルプロマジン 塩酸塩, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
SMILES string
Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
InChI key
FBSMERQALIEGJT-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
chlorpromazine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)
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関連するカテゴリー
Application
ヘモグロビンやペルオキシダーゼの微量定量において、ベンジジン、o-ジアニシジン、o-トリジンの代わりに用いられます。
Biochem/physiol Actions
クロルプロマジンは、白血病細胞に対する細胞毒性と抗増殖活性がありますが、正常なリンパ球の生存率には影響を与えません。
フェノチアジン系抗精神病薬であり、D2ドーパミンレセプターおよびH1ヒスタミンレセプターのアンタゴニストです。サイクリックヌクレオチドホスホジエステラーゼやNOシンターゼによるカルモジュリン依存性刺激作用を阻害します。
General description
この製品は薬局方標準品です。発行元の薬局方により製造・供給されています。MSDSを含む製品情報などの詳しい情報は、発行元の薬局方のウェブサイトよりご確認ください。
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells. Generation of reactive
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Phenothiazines when exposed to white light or to UV radiation undergo a variety of reactions that result in degradation of parental compound and formation of new species. This process is slow and may be sped up with exposure to high
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In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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