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この商品について
実験式（ヒル表記法）:
C8H15N7O2S3
CAS番号:
分子量:
337.45
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
SMILES string
N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
InChI key
XUFQPHANEAPEMJ-UHFFFAOYSA-N
biological source
synthetic
grade
pharmaceutical primary standard
agency
EP Reference Standard
API family
famotidine
form
solid
packaging
pkg of 110 mg
manufacturer/tradename
EDQM
storage condition
protect from light
application(s)
pharmaceutical (small molecule)
format
neat
shipped in
ambient
storage temp.
2-8°C
Gene Information
human ... HRH2(3274)
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General description
Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
H2ヒスタミンレセプタ-のアンタゴニストであり、抗潰瘍薬です。
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Famotidine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 29(1-2), 2609-2610 (2017)
Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones
Campbell AN and Sherma J
Journal of Liquid Chromatography and Related Technologies, 26(16), 2719-2727 (2003)
Stability indicating method for famotidine in pharmaceuticals using porous graphitic carbon column
Helali N and Monser L
Journal of Separation Science, 31(2) (2008)
H Echizen et al.
Clinical pharmacokinetics, 21(3), 178-194 (1991-09-01)
Famotidine is a potent histamine H2-receptor antagonist widely used in the treatment and prevention of peptic ulcer disease. After intravenous administration the plasma famotidine concentration-time profile exhibits a biexponential decay, with a distribution half-life of about 0.18 to 0.5h and
L P James et al.
Clinical pharmacokinetics, 31(2), 103-110 (1996-08-01)
Famotidine, an H2 receptor antagonist, has several potential advantages over cimetidine and ranitidine. These advantages include its potency, relatively longer elimination half-life, and lack of interaction with the cytochrome P450 isoforms. Eight studies addressing the use of famotidine in paediatric
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