PHR1242
L-ﾄレオニン
Pharmaceutical Secondary Standard; Certified Reference Material
別名:
(2S,3R)-2-アミノ-3-ヒドロキシ酪酸
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この商品について
化学式:
CH3CH(OH)CH(NH2)CO2H
CAS番号:
分子量:
119.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-774-1
Beilstein/REAXYS Number:
1721646
MDL number:
製品名
L-ﾄレオニン, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChI key
AYFVYJQAPQTCCC-GBXIJSLDSA-N
SMILES string
C[C@@H](O)[C@H](N)C(O)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. T1340000
traceable to USP 1667202
API family
l-threonine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
256 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
L-Threonine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
L-Threonine is an essential amino acid. It is involved in the synthesis of mucin, a protein supporting intestinal function and integrity. L-threonine has a role in the immune system, in O-linked glycosylation, protein phosphorylation and glycine synthesis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9046 in the slot below. This is an example certificate only and may not be the lot that you receive.
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
PHR1242-500MG-PW: + PHR1242-500MG:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
HPLC-fluorescence determination of amino acids in pharmaceuticals after pre-column derivatization with phanquinone
Gatti.R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 35(2), 339-348 (2004)
Chang-Ching Liu et al.
Molecular and cellular biology, 34(1), 57-70 (2013-10-30)
In budding yeast (Saccharomyces cerevisiae), the cell cycle-dependent telomere elongation by telomerase is controlled by the cyclin-dependent kinase 1 (Cdk1). The telomere length homeostasis is balanced between telomerase-unextendable and telomerase-extendable states that both require Cdc13. The recruitment of telomerase complex
Na Wang et al.
Cancer, 120(19), 2965-2979 (2014-06-06)
The telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T have been found in many malignancies, including in thyroid carcinomas. However, it is unclear how early these mutations occur in thyroid tumorigenesis. The study included primary tumors from 58 patients
Patricia Seoane-Collazo et al.
Endocrinology, 155(5), 1679-1689 (2014-02-13)
Nicotine, the main addictive component of tobacco, promotes body weight reduction in humans and rodents. Recent evidence has suggested that nicotine acts in the central nervous system to modulate energy balance. Specifically, nicotine modulates hypothalamic AMP-activated protein kinase to decrease
Anne-Sophie Van Rompuy et al.
Journal of neuropathology and experimental neurology, 73(2), 159-174 (2014-01-16)
Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson disease (PD). The pathogenic mechanisms of how parkin mutations lead to the development of PD are not fully understood. Studies of cell cultures and of
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