(+)-Tubocurarine chloride pentahydrate

Name: (+)-Tubocurarine chloride pentahydrate
Brand: SIGMA

From plant, ≥97.0% (TLC), nicotinic acetylcholine receptor antagonist, powder

別名:

(+)-Tubocurarine chloride hydrochloride pentahydrate, D-Tubocurarine dichloride pentahydrate, Tubarine pentahydrate

ログインで組織・契約価格をご覧ください。

サイズを選択してください

この商品について

実験式（ヒル表記法）:

C₃₇H₄₂Cl₂N₂O₆ · 5H₂O

CAS番号:

6989-98-6

分子量:

771.72

NACRES:

NA.77

PubChem Substance ID:

57653575

UNSPSC Code:

12352202

MDL number:

MFCD00150157

Beilstein/REAXYS Number:

3896374

Assay:

≥97.0% (TLC)

Form:

powder

主要文書

すべての文書を表示

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

製品名

(+)-Tubocurarine chloride pentahydrate, ≥97.0% (TLC)

InChI

1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

SMILES string

[Cl-].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4

InChI key

WMIZITXEJNQAQK-GGDSLZADSA-N

biological source

plant

assay

≥97.0% (TLC)

form

powder

optical activity

[α]20/D +195±5°, c = 0.5% in H₂O

impurities

~12% water

mp

275-280 °C (dec.) (lit.)

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

類似した製品をお探しですか？訪問製品比較ガイド

Application

(+)-Tubocurarine chloride pentahydrate has been used:

as an acetylcholine receptor antagonist in synapse blocking experiment to study its effect on neuromuscular junction formation (NMJ) formation in a co-culture system of human skeletal muscles and human stem cell-derived motoneurons
to induce paralysis in zebrafish larvae to study whole-brain imaging of seizures by two-photon light-sheet microscopy
to block NMJ to study its role in myotube contraction

Biochem/physiol Actions

(+)-Tubocurarine chloride pentahydrate serves as a neuromuscular blocker.

Classical competitive antagonist of the nicotinic acetylcholine receptor. Structure-activity relationships and conformational studies for tubocurarine binding at the nicotinic AChR.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

93750-VAR: + 93750-250MG:4548173183725 + 93750-BULK: + 93750-1G:4548173183718

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Interaction of d-tubocurarine analogs with the mouse nicotinic acetylcholine receptor. Ligand orientation at the binding site.

R V Papineni et al.

The Journal of biological chemistry, 272(40), 24891-24898 (1997-10-06)

The binding of d-tubocurarine and several of its analogs to the mouse nicotinic acetylcholine receptor (AChR) was measured by competition against the initial rate 125I-alpha-bungarotoxin binding to BC3H-1 cells. The changes in affinity due to methylation or halogenation at various

Acetylcholine receptor inhibition by d-tubocurarine involves both a competitive and a noncompetitive binding site as determined by stopped-flow measurements of receptor-controlled ion flux in membrane vesicles.

J W Karpen et al.

Biochemistry, 25(7), 1786-1792 (1986-04-08)

The issue of whether d-tubocurarine, the classical acetylcholine receptor inhibitor, inhibits the receptor by a competitive or noncompetitive mechanism has long been controversial. d-Tubocurarine, in this study, has been found to be both a competitive (KC = 120 nM) and

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.

Richard Mills et al.

Molecular metabolism, 7, 12-22 (2017-11-22)

We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. A microfluidic device was used to model endocrine signaling and NMJ formation between primary mouse myoblast-derived myotubes and embryonic stem cell-derived motor

Fast whole-brain imaging of seizures in zebrafish larvae by two-photon light-sheet microscopy

de Vito G, et al.

Biomedical Optics Express, 1516-1536 null

Power-effective scanning with AODs for 3D optogenic applications.

Pietro Ricci et al.

Journal of biophotonics, 15(4), e202100256-e202100256 (2022-01-10)

Two-photon (2P) excitation is a cornerstone approach widely employed in neuroscience microscopy for deep optical access and sub-micrometric-resolution light targeting into the brain. However, besides structural and functional imaging, 2P optogenetic stimulations are less routinary, especially in 3D. This is

(+)-Tubocurarine chloride pentahydrate

From plant, ≥97.0% (TLC), nicotinic acetylcholine receptor antagonist, powder

サイズを選択してください

この商品について

主要文書

特性

製品名

InChI

SMILES string

InChI key

biological source

assay

form

optical activity

impurities

mp

storage temp.

Quality Level

Gene Information

関連するカテゴリー

詳細

Application

Biochem/physiol Actions

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

93750-VAR: + 93750-250MG:4548173183725 + 93750-BULK: + 93750-1G:4548173183718

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

テクニカルサービス