A1987
AM6545
≥98% (HPLC)
別名:
5-(4-[4-シアノブタ-1-イニル]フェニル)-1-(2,4-ジクロロフェニル)-4-メチル-N-(1,1-ジオキソ-チオモルホリノ)-1H-ピラゾール-3-カルボキサミド
ログインで組織・契約価格をご覧ください。
サイズを選択してください
この商品について
実験式（ヒル表記法）:
C26H23Cl2N5O3S
CAS番号:
分子量:
556.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
AM6545, ≥98% (HPLC)
InChI key
XBHQLFVDGLPBCK-UHFFFAOYSA-N
SMILES string
Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4
InChI
1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >25 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
AM6545は、アルブミン尿の発症、炎症、および線維症のマーカー発現を減少させるのに役立ちます。また、ネフリンとポドシンの発現減弱（ダウンレギュレーション）にも役立ちます。食物の摂取と食物増強行動を抑制する能力を有しています。
AM6545は、末梢性CB1カンナビノイド受容体であり、食欲抑制薬です。
Features and Benefits
この化合物はHandbook of Receptor Classification and Signal Transductionのカンナビノイド受容体のページに取り上げられています。ハンドブックのその他のページをご覧になるには、ここをクリックしてください。
General description
AM6545はカンナビノイド（CB1）受容体アンタゴニストです。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Michael Ameismeier et al.
Nature, 587(7835), 683-687 (2020-11-20)
Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2.
Songqing Tang et al.
Nature communications, 5, 4657-4657 (2014-08-15)
Host immune cells can detect and destruct invading pathogens via pattern-recognition receptors. Small Rap GTPases act as conserved molecular switches coupling extracellular signals to various cellular responses, but their roles as regulators in Toll-like receptor (TLR) signalling have not been
Donovan A Argueta et al.
Physiology & behavior, 171, 32-39 (2017-01-10)
The endocannabinoid system in the brain and periphery plays a major role in controlling food intake and energy balance. We reported that tasting dietary fats was met with increased levels of the endocannabinoids, 2-arachidonoyl-sn-glycerol (2-AG) and anandamide, in the rat
Yi-Seul Yoon et al.
BMB reports, 53(3), 166-171 (2020-01-23)
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle. Dose-dependent inhibition of Ebola trVLP replication was induced by 15 hit compounds, which primarily
Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy
Barutta F, et al.
British Journal of Pharmacology, 175(23), 4371-4385 (2018)
資料
We offer many products related to cannabinoid receptors for your research needs.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）