E5630
β-エストラジオール6-(O-カルボキシメチル)オキシム:BSA
mitogen-activated protein kinase (MAPK) stimulator, lyophilized powder
製品名
β-エストラジオール6-(O-カルボキシメチル)オキシム:BSA,
sterility
non-sterile
form
lyophilized powder
extent of labeling
~30 mol steroid per mol BSA
solubility
phosphate buffer: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
Quality Level
General description
β-Estradiol 6-(O-carboxymethyl)oxime: BSA is an estradiol conjugate and is membrane-impermeable. BSA is linked to the estradiol at position 6 to form the β-estradiol 6-(O-carboxymethyl) oxime: BSA conjugate.
Application
β-Estradiol 6-(O-carboxymethyl)oxime: BSA has been used:
- to test its effect on the N-methyl-D-aspartate receptor (NMDAR) currents in female dorsal root ganglion (DRG) neurons
- to coat microplates for the detection of plasma 17β-Estradiol levels using indirect enzyme-linked immunosorbent assay (ELISA)
- to test its effect on MutL homolog 1 in colorectal cancer lines
Biochem/physiol Actions
β-Estradiol 6-(O-carboxymethyl)oxime: BSA mimics estrogen and favors amyloid precursor protein α (sAPPα) secretion in vitro studies with primary rat cortical neurons. It also stimulates mitogen-activated protein kinase (MAPK) activity in human umbilical vein endothelial cells
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
E5630-5MG-PW: + E5630-25MG: + E5630-BULK: + E5630-100MG: + E5630-5MG: + E5630-1MG: + E5630-10MG-PW: + E5630-VAR: + E5630-10MG:
jan
Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons.
McRoberts, et al.
Neuroscience, 148, 1015-1020 (2018)
K S Russell et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(11), 5930-5935 (2000-05-24)
Estrogen induces both rapid and delayed effects on the cardiovascular system. The early effects take place within minutes (e.g., changes in vasomotor tone) and are mediated through rapid intracellular signaling pathways; whereas the delayed effects (e.g., remodeling or lipid alterations)
Adrián Tintos et al.
Ecotoxicology and environmental safety, 66(2), 139-147 (2006-02-10)
To assess the effects of naphthalene on liver intermediary metabolism and plasma steroid hormones, immature female rainbow trout (Oncorhynchus mykiss), in a first experiment, were intraperitoneally injected (2 microLg(-1)) with vegetable oil alone (control) or containing naphthalene (10 and 50
Claudio R F Marinho et al.
PloS one, 4(5), e5630-e5630 (2009-05-23)
Pregnancy-associated malaria (PAM) is associated with placenta pathology and poor pregnancy outcome but the mechanisms that control the malaria parasite expansion in pregnancy are still poorly understood and not amenable for study in human subjects. Here, we used a set
Yu-Jie Lai et al.
Journal of molecular neuroscience : MN, 61(3), 436-448 (2017-02-06)
Estrogen exerts multiple actions in the brain and is an important neuroprotective factor in a number of neuronal disorders. However, the underlying mechanism remains unknown. Studies demonstrate that ubiquitin-conjugating enzyme 9 (ubc9) has an integral role in synaptic plasticity and
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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