製品名
フィブロネクチン, lyophilized powder, 70 kDa
biological source
human plasma
assay
>90% (SDS-PAGE)
form
lyophilized powder
mol wt
70 kDa
packaging
pkg of 0.5 mg
technique(s)
cell culture | mammalian: suitable
impurities
HIV and HBsAg, source material tested negative
Small proteolytic fragments, may contain traces
solubility
water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... FN1(2335)
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Disclaimer
凍結乾燥品(PBS, 凍結保護剤としてスクロ-ス含有)
Preparation Note
70 kDaのこのN末端断片は、カテプシンDの消化により得られます。
Application
Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.
Biochem/physiol Actions
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.
General description
Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fibronectin in Health and Disease (2018)
Mutations F352A and Y528A in human HSP90I? reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Chakraborty, et al.
Cell Stress & Chaperones (2023)
Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
プロトコル
Dilute fibronectin for cell attachment, varying per cell type. Coating protocol, products, and FAQs provided.
関連コンテンツ
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