G9518

ゲムフィブロジル

Name: ゲムフィブロジル
Brand: SIGMA

PPARα and PPARγ agonist, powder

別名:

2,2-ジメチル-5-(2,5-ジメチルフェノキシ)ペンタン酸

ログインで組織・契約価格をご覧ください。

サイズを選択してください

この商品について

実験式（ヒル表記法）:

C₁₅H₂₂O₃

CAS番号:

25812-30-0

分子量:

250.33

NACRES:

NA.77

PubChem Substance ID:

24895377

UNSPSC Code:

12352200

EC Number:

247-280-2

MDL number:

MFCD00079335

主要文書

すべての文書を表示

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

製品名

ゲムフィブロジル,

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChI key

HEMJJKBWTPKOJG-UHFFFAOYSA-N

SMILES string

Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1

form

powder

Quality Level

100

Gene Information

human ... PPARA(5465)

類似した製品をお探しですか？訪問製品比較ガイド

General description

Gemfibrozil is a fibric acid derivative and a hypolipidemic drug. Gemfibrozil serves as a ligand for PPARα (peroxisome proliferator-activated receptor α).

Application

Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.

Biochem/physiol Actions

Gemfibrozil selectively increases Apolipoprotein A-I levels. In yeast cells, application of gemfibrozil delays the start of DNA replication. It is used as a therapeutic agent for dyslipidemia.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 + P330 - P501

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

G9518-BULK: + G9518-5G: + G9518-25G: + G9518-VAR: + G9518-1G:

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning.

Katerina Cizkova et al.

Lipids in health and disease, 15(1), 164-164 (2016-09-24)

Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been considered as potential anticancer agents. We studied effect of fibrates treatment on cell proliferation, expression of CYP2J2 and concomitant

Effects of Fenofibrate and Gemfibrozil on Kynurenic Acid Production in Rat Kidneys In Vitro: Old Drugs, New Properties.

Izabela Zakrocka et al.

Life (Basel, Switzerland), 13(11) (2023-11-25)

Kidney dysfunction significantly increases the cardiovascular risk, even in cases of minor functional declines. Hypertriglyceridemia is the most common lipid abnormality reported in patients with kidney disorders. PPAR-α (peroxisome proliferator-activated receptor-α) agonists called fibrates are the main agents used to

Impact of the Physical Cellular Microenvironment on the Structure and Function of a Model Hepatocyte Cell Line for Drug Toxicity Applications.

Benjamin Allcock et al.

Cells, 12(19) (2023-10-13)

It is widely recognised that cells respond to their microenvironment, which has implications for cell culture practices. Growth cues provided by 2D cell culture substrates are far removed from native 3D tissue structure in vivo. Geometry is one of many

Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine.

Scott A Hoose et al.

PloS one, 7(5), e36503-e36503 (2012-05-09)

Screening chemical libraries to identify compounds that affect overall cell proliferation is common. However, in most cases, it is not known whether the compounds tested alter the timing of particular cell cycle transitions. Here, we evaluated an FDA-approved drug library

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil.

Ana Maria Sierra Villar et al.

International journal of pharmaceutics, 431(1-2), 161-175 (2012-04-14)

Self-nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the

資料

Discover Bioactive Small Molecules for Lipid Signaling Research

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Discover Bioactive Small Molecules for ADME/Tox

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

製品に関するお問い合わせはこちら（テクニカルサービス）

ゲムフィブロジル

PPARα and PPARγ agonist, powder

サイズを選択してください

この商品について

主要文書

特性

製品名

InChI

InChI key

SMILES string

form

Quality Level

Gene Information

関連するカテゴリー

詳細

General description

Application

Biochem/physiol Actions

Features and Benefits

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

G9518-BULK: + G9518-5G: + G9518-25G: + G9518-VAR: + G9518-1G:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

プロトコルと関連資料

資料

テクニカルサービス