H7779
レチノイン酸 p-ヒドロキシアニリド
≥95%
別名:
4-HPR, N-(4-ヒドロキシフェニル)レチンアミド, フェンレチニド
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この商品について
実験式（ヒル表記法）:
C26H33NO2
CAS番号:
分子量:
391.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
製品名
レチノイン酸 p-ヒドロキシアニリド, ≥95%
InChI
1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
InChI key
AKJHMTWEGVYYSE-FXILSDISSA-N
biological source
synthetic (organic)
assay
≥95%
form
powder
color
yellow to yellow-orange
storage temp.
−20°C
Quality Level
関連するカテゴリー
Application
Retinoic acid p-hydroxyanilide has been used:
- as a synthetic retinoid to induce apoptosis in SEB-1 sebocytes
- as a medium supplement for C2C12 myoblasts to test its effect on ceramide formation
- to test in cytotoxicity in T-cell acute lymphoblastic leukemia (T-ALL)
Biochem/physiol Actions
Retinoic acid p-hydroxyanilide, also called fenretinide, increases reactive oxygen species, activates caspases and induces apoptosis. It also inhibits dihydroceramide desaturase, leading to a decrease in ceramide biosynthesis. Fenretinide may elicit anticancer activity in cultured human breast cancer cells. It acts as an insulin antagonist and may be useful in treating insulin resistance. Fenretinide or 4-HPR has chemotherapeutic potential and is cytotoxic to retinoic acid-resistant cancers.
Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.
General description
Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Journal of molecular medicine (Berlin, Germany), 95(10), 1053-1064 (2017-07-12)
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In the absence of approved therapeutics, Zika virus (ZIKV)'s recent prolific outbreaks in the Americas, together with impacts on unborn fetuses of infected mothers, make it a pressing human health concern worldwide. Although a key player in viral replication in
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Streptococcus suis is an important swine pathogen and an emergent zoonotic pathogen. Excessive inflammation caused by S. suis is responsible for early high mortality in septic shock-like syndrome cases. Polyunsaturated fatty acids (PUFAs) may contribute to regulating inflammatory processes. This
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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