I0523
IL-2 mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
別名:
mIL-2, IL-2, T細胞増殖因子
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この商品について
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
17.2 kDa
Impurities:
≤1.000 EU/μg
製品名
インターロイキン-2 マウス由来, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
≤0.2 ng/mL ED50
quality
endotoxin tested
mol wt
17.2 kDa
packaging
pkg of 5X20 μg
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Il2(16183)
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Physical form
Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.
Analysis Note
活性は、マウスCTLL-2細胞の用量依存的な刺激作用により決定しています。ED50:≦0.2 ng/mL(比活性5×106 units/mg相当)。
Application
Interleukin-2 from mouse has been used to induce sepsis in rat model. It has also been used in dendritic epidermal T cell culture.
Biochem/physiol Actions
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long-term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of natural killer cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. IL-2 expression is known to reduce with age and results in influenza infection, neoplasms and lethal autoimmunity. IL-2 participates in T cell proliferation and differentiation and controls the homeostasis of T cell. As a part of immune response, IL-2 stimulates the action of T helper cell 1 and 2 along with endothelial white blood cells of skeletal muscles. IL-2 regulation is controlled by c-rel protein. IL-2 is a neurotrophic molecule and has special functions in cortical, hippocampal, septal, cerebellar and retinal neurons.
General description
IL-2 (interleukin-2) codes for a pro-inflammatory cytokine. IL-2 is mostly expressed in T helper cells.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Krithika Badarinath et al.
Methods in molecular biology (Clifton, N.J.), 1879, 285-297 (2018-06-14)
The interplay of immune cells and stem cells in maintaining skin homeostasis and repair is an exciting new frontier in cutaneous biology. With the growing appreciation of the importance of this new crosstalk comes the requirement of methods to interrogate
A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2
Studena S, et al.
Biological & Pharmaceutical Bulletin, 35(10), 1703-1710 (2012)
Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4+ T cells of aged rats
Gong Z, et al.
Molecular Immunology, 61, 1-6 (2014)
Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina
Marra C, et al.
Journal of Neuroimmunology, 233(1-2), 120-126 (2011)
Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats
Neto JCR, et al.
Lipids in Health and Disease, 10, 97-97 (2011)
資料
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
関連コンテンツ
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