I4034
インメピップ 二臭化水素酸塩
≥97% (HPLC), H3 and H4 histamine receptor agonist, powder
別名:
4-(1H-イミダゾール-4-イルメチル)ピペリジン二臭化水素酸塩
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この商品について
実験式（ヒル表記法）:
C9H17N3Br2
CAS番号:
分子量:
327.06
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
インメピップ 二臭化水素酸塩, ≥97% (HPLC), powder
SMILES string
Br.Br.C1CNCC(C1)Cc2c[nH]cn2
InChI key
FXFINNKFZKZVLS-UHFFFAOYSA-N
InChI
1S/C9H15N3.2BrH/c1-2-8(5-10-3-1)4-9-6-11-7-12-9;;/h6-8,10H,1-5H2,(H,11,12);2*1H
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
関連するカテゴリー
Biochem/physiol Actions
H3, H4ヒスタミンレセプタ-のアゴニストです。
インメピップはH3およびH4ヒスタミン受容体アゴニストです。インメピップは選択的なH3 アゴニストであり、(R)-α-メチルヒスタミンと同等の作用強度を持ち、in vitroおよびin vivoで有効です。H1 レセプタ-、α2 レセプタ-、5-HT3レセプタ-で誘発される副作用はみられません。
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
I4034-10MG: + I4034-BULK-CR: + I4034-50MG: + I4034-BULK: + I4034-VAR:
jan
Jitendra K Singh et al.
Annals of neurosciences, 19(2), 71-75 (2012-04-01)
The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic functions. This receptor exhibits molecular, pharmacological, and functional heterogeneity that affects
Guadalupe-Elide Morales-Figueroa et al.
Purinergic signalling, 15(1), 85-93 (2018-12-20)
We previously reported that the activation of histamine H3 receptors (H3Rs) selectively counteracts the facilitatory action of adenosine A2A receptors (A2ARs) on GABA release from rat globus pallidus (GP) isolated nerve terminals (synaptosomes). In this work, we examined the mechanisms
Balasubramaniam Annamalai et al.
ACS chemical neuroscience, 11(3), 466-476 (2020-01-10)
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H3 histamine receptors (H3Rs)
Nayeli Rivera-Ramírez et al.
Neurochemistry international, 101, 38-47 (2016-11-05)
The histamine H3 receptor (H3R) is abundantly expressed in the Central Nervous System where it regulates several functions pre and postsynaptically. H3Rs couple to Gαi/o proteins and trigger or modulate several intracellular signaling pathways, including the cAMP/PKA pathway and the
Gustavo Nieto-Alamilla et al.
Journal of receptor and signal transduction research, 38(2), 141-150 (2018-03-21)
In stably-transfected human neuroblastoma SH-SY5Y cells, we have compared the effect of activating two isoforms of 445 and 365 amino acids of the human histamine H3 receptor (hH3R445 and hH3R365) on [35S]-GTPγS binding, forskolin-induced cAMP formation, depolarization-induced increase in the
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