I6658
Isradipine
≥98% (HPLC), calcium channel blocker, solid
別名:
4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester
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この商品について
実験式（ヒル表記法）:
C19H21N3O5
CAS番号:
分子量:
371.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
Isradipine, ≥98% (HPLC), solid
description
Store under nitrogen
Quality Level
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: >10 mg/mL
originator
Novartis
storage temp.
2-8°C
SMILES string
COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C
InChI
1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChI key
HMJIYCCIJYRONP-UHFFFAOYSA-N
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781)
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Application
Isradipine has been used to explore neuroprotective activity.
Biochem/physiol Actions
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.
L-type calcium channel blocker; antihypertensive.
Isradipine is considered as an active calcium channel blocker, used to treat hypertension.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Dalton James Surmeier et al.
Antioxidants & redox signaling, 14(7), 1289-1301 (2010-08-18)
Parkinson's disease (PD) is a major world-wide health problem afflicting millions of the aged population. Factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and environmental toxins, have dominated public discussions of disease etiology. Although
Thimmappa S Anekonda et al.
Neurobiology of disease, 41(1), 62-70 (2010-09-08)
There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and death. Here we investigated the feasibility
Fernando A Aguiar et al.
Electrophoresis, 32(19), 2673-2682 (2011-10-11)
A simple enantioselective method based on CE using CD as chiral selector was developed and validated for the determination of isradipine (IRD) enantiomers in a pharmaceutical formulation and for the determination of IRD enantiomers in degradation studies. After optimization, the
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.
E Ilijic et al.
Neurobiology of disease, 43(2), 364-371 (2011-04-26)
The motor symptoms of Parkinson's disease (PD) are due to the progressive loss of dopamine (DA) neurons in substantia nigra pars compacta (SNc). Nothing is known to slow the progression of the disease, making the identification of potential neuroprotective agents
Vincent Malaterre et al.
International journal of pharmaceutics, 376(1-2), 56-62 (2009-04-23)
Despite more than 30 years of clinical use, only few studies have been published reporting on the release mechanism underlying the drug delivery from push-pull osmotic pumps (PPOP). The aim of this study is to understand which factors have an
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