K1388
KT5823
≥85% (HPLC), lyophilized powder
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この商品について
実験式（ヒル表記法）:
C29H25N3O5
CAS番号:
分子量:
495.53
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
KT 5823, ≥85% (HPLC), lyophilized powder
SMILES string
COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC
InChI key
QTYMDECKVKSGSM-YMUMJAELSA-N
InChI
1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
assay
≥85% (HPLC)
form
lyophilized powder
color
white
solubility
ethyl acetate: 5 mg/mL
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
Biochem/physiol Actions
PKGの選択的インヒビタ-です。
Application
KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na+/I− symporter (NIS) expression.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A N Meints et al.
Journal of neuroendocrinology, 24(8), 1166-1181 (2012-04-11)
Nitric oxide synthase (NOS) immunoreactivity is present in goldfish gonadotrophs. The present study investigated whether two native goldfish gonadotrophin-releasing hormones (GnRHs), salmon (s)GnRH and chicken (c)GnRH-II, use NOS/nitric oxide (NO) and soluble guanylate cyclase (sGC)/cyclic (c)GMP/protein kinase G (PKG) signalling
PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.
Harraz OF, et al.
eLife, 7(6), e38689-e38689 (2018)
Fei Sun et al.
Frontiers in cell and developmental biology, 9, 681421-681421 (2021-07-17)
Sensorineural hearing loss (SNHL) is a dominant public health issue affecting millions of people around the globe, which is correlated with the irreversible deterioration of the hair cells and spiral ganglion neurons (SGNs) within the cochlea. Strategies using bioactive molecules
Junhui Sun et al.
Free radical biology & medicine, 54, 105-112 (2012-09-20)
Nitric oxide (NO) plays an important role in acute ischemic preconditioning (IPC). In addition to activating soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) signaling pathways, NO-mediated protein S-nitros(yl)ation (SNO) has been recently shown to play an essential
KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
Burkhardt M, et al.
The Journal of Biological Chemistry, 275(43), 33536-33541 (2000)
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