K2628
ケトチフェン フマル酸塩
≥99% (TLC), powder, H₁ histamine receptor antagonist
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この商品について
実験式（ヒル表記法）:
C19H19NOS · C4H4O4
CAS番号:
分子量:
425.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
252-100-0
MDL number:
Form:
powder
Quality level:
製品名
ケトチフェン フマル酸塩,
InChI key
YNQQEYBLVYAWNX-WLHGVMLRSA-N
InChI
1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES string
OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24
form
powder
originator
Novartis
Quality Level
Gene Information
human ... HRH1(3269), PDE7B(27115)
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関連するカテゴリー
Application
Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water
Biochem/physiol Actions
H1 histamine receptor antagonist.
Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Ketotifen fumarate salt is an antihistamine drug.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
K2628-BULK: + K2628-1G: + K2628-VAR: + K2628-100MG: + K2628-500MG:
jan
William L
Anabolics (2011)
Jeffrey KA
Side Effects of Drugs Annual (2005)
X Lin et al.
Life sciences, 63(2), 145-153 (1998-07-23)
The Differential Display technique has been used to identify differences in mRNA expression in adipose tissue after the introduction of a high fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity
Michael J Monument et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(4), 285-292 (2011-12-17)
Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would lessen the molecular manifestations of joint capsule fibrosis. Surgical joint injury was used to create stable post-traumatic contractures of
Mast Cells in the Developing Brain Determine Adult Sexual Behavior
Lenz KM, et al.
The Journal of Neuroscience, 38(37), 8044-8059 (2018)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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